In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly, new original therapeutic strategies to increase potency, selectivity and decrease detrimental side effects have been evaluated. Here we review some recent advances in targeting cancer.

OBJECTIVES To investigate the longitudinal association of nailfold capillary density (NCD; as a potential marker of activity) with various other clinical measures of disease activity and to evaluate baseline NCD as a predictor of disease outcome in children with JDM. METHODS Data from 809 clinic visits from 92 JDM patients were prospectively collected at each clinic visit over a time period o...

Core-shell nanostructures are emerging as more important materials than alloy nanostructures and have much more interesting potential applications in various fields. In this work, we demonstrated the fast and facile synthesis of core-shell nanoparticles consisting of Pt thin layer as the shell and Ni nanoparticles as the cores. The described method herein is suitable for large-scale and low-cos...

This paper focuses on the impact of cyberspace on religiosity in Iran through reviewing previous studies. The situation of religion in the age of the internet has always been a major matter of concern for Iranian scholars and policy makers. Accordingly, there have been many researchers who have addressed and approached this problem but there has been no comprehensive understanding of the impact...

or certain more curious and disenchanted spirits, the pleasure of ugliness comes from an even more mysterious sentiment, which is a thirst for the unknown and a taste for the horrible, " wrote Charles Baudelaire. " It is this sentiment, the germ of which all of us carry inside to a greater or lesser degree, that drives certain poets into clinics and anatomy theaters, and women to public executi...

During the past two decades, antibiotic resistance among nosocomial pathogens has gone from bad to worse. According to intensive care unit (ICU) data from U.S. hospitals participating in the National Nosocomial Infections Surveillance System of the Centers for Disease Control and Prevention during the year 2000, 55% of nosocomial Staphylococcus aureus isolates were resistant to methicillin, 26%...