The expression of distinct keratin pairs during epidermal differentiation is assumed to fulfill specific and essential cytoskeletal functions. This is supported by a great variety of genodermatoses exhibiting tissue fragility because of keratin mutations. Here, we show that the loss of K10, the most prominent epidermal protein, allowed the formation of a normal epidermis in neonatal mice withou...

Vitamin D3 analogues are a first-line treatment of chronic plaque psoriasis, but so far, comparative clinical studies on calcipotriol and calcitriol ointment are sparse, and in particular no comparative studies are available on cell biological effects of these compounds in vivo. Using flow cytometric assessment, we investigated whether these compounds had different effects on the composition an...

Kinetin (N(6)-furfuryladenine) is a cytokinin growth factor having several anti-aging effects reported for human cells and fruit flies. We have observed that short-term culturing of human keratinocytes in the presence of 40 to 200 microM kinetin results in a significant inhibition of cell growth. Studies were undertaken to analyze the process of differentiation as a reason for growth inhibition...

Although human diseases of retrotransposition-derived etiology have been documented, retrotransposon RNA expression and the occurrence of retrotransposition events in the human oocyte are not studied. We investigated the RNA expression of L1 and HERV-K10 retrotransposons in human oocytes by RT-PCR analysis with designed primers. Using denucleated germinal vesicles (GVs), we detected RT-PCR prod...

Background: Ramsar, a northern city in Iran, lies on the coast of the Caspian Sea. This city has areas with some of the highest levels of natural radiation measured to date. The radon concentration in some areas of Ramsar is up to 3700 Bq m–3. On the other hand, due to high level of humidity, damp-proof barriers should be used in construction of new buildings in radon prone areas of this cit...

-The effect of ethylene oxide-sterilization on homoionic (Na +, K § Ca 2+, Cu 2+, A1 s+, and Fe 3+) montmorillonite samples was examined. The results indicate that ethylene oxide polymerized to polyethylene glycol in the interlayer of Cu 2+-, AP +-, and FeS+-saturated clays, as substantiated by the increase in the d(001) values, as well as by the decrease in the cation-exchange capacity after r...

Our continuing research on the preparation, characterization, materials properties, and biodegradability of polylactide (PLA)/organically modified layered silicate (OMLS) nanocomposites has yielded results on PLA/montmorillonite nanocomposites. Montmorillonite (mmt) modified with dimethyldioctadecylammonium cation was used as an OMLS for nanocomposite preparation. The internal structure of nano...

the aim of this study was to investigate the rate of water vapor permeability (wvp) and moisture sorption of starch-montmorillonite (mmt) nanocomposite films. the nanocomposite films were prepared using the casting method andglycerol was used as a plasticizer. the effect of glycerol concentration on wvp of the films was determined at 25°c with a relative humidity of 0-99% (inside and outside of...

STUDY OF CONTROLLED RELEASE OF DAPSONE FROM MODIFIED MONTMORILLONITE AND POLYMER MATRICES