OBJECTIVE To evaluate the relationships between the amount and type of dietary fat and intermediate age-related macular degeneration (AMD). DESIGN Women aged 50 to 79 years with high and low lutein intake from 3 sites of the Women's Health Initiative Observational Study were recruited into the Carotenoids in Age-Related Eye Disease Study. Fat intake from 1994 through 1998 was estimated using ...

BACKGROUND Dietary fatty acids that are more prone to oxidation than to storage may be less likely to lead to obesity. OBJECTIVE The aim of this study was to determine the effect of chain length, degree of unsaturation, and stereoisomeric effects of unsaturation on the oxidation of individual fatty acids in normal-weight men. DESIGN Fatty acid oxidation was examined in men consuming a weigh...

OBJECTIVE To determine the effect of a high-protein (HP) weight loss diet compared with a lower-protein (LP) diet on fat and lean tissue and fasting and postprandial glucose and insulin concentrations. RESEARCH DESIGN AND METHODS Replacing dietary protein for carbohydrate (CHO) during energy restriction and weight loss has been effective in sparing lean mass and improving insulin sensitivity ...

Refeeding starved rats a fat-free diet over a 48 hr period brings about a marked elevation in the activity of the enzymes in liver cytoplasm which catalyze the synthesis of saturated fatty acids from acetyl CoA and malonyl CoA. Acetate incorporation into palmitoleic and oleic acid is also accelerated during this period. Enhanced capability for the synthesis of these fatty acids is reflected in ...

BACKGROUND Disarrangement in fatty acids and oxidative stress are features of cystic fibrosis. Cholesterol is very sensitive to oxidative stress. OBJECTIVES The objectives were to examine whether cholesterol oxidation products are altered in cystic fibrosis and whether they are associated with fatty acids and with characteristics of the disease state. DESIGN 7-Ketocholesterol and 7beta-hydr...

Six different types of cancer (i.e., breast, lung, colorectal, esophageal, gastric, and thyroid cancer) have high rates of incidence or mortality worldwide. It has been shown that activation of de novo lipogenesis is an early and common event in the cancer microenvironment. In this study, we performed lipid imaging and profiling for 134 tissue samples from six different types of cancer using ma...