The present study compared beta-lactam macrolide ("combination") therapy versus beta-lactam alone ("monotherapy") for hospitalised community-acquired pneumonia, using propensity scores to adjust for the differences between patients. A prospective multinational observational study was carried out. Baseline patient and infection characteristics were used to develop a propensity score for combinat...

BACKGROUND For patients with advanced gastric cancer (AGC), second-line chemotherapy regimen remains controversial. The efficacy and safety of irinotecan-containing doublet treatment and irinotecan monotherapy were compared in this systematic analysis. METHODS A search was conducted on EMBASE and Medline databases. All articles compared irinotecan-containing doublet to irinotecan as second-li...

---------------------------INDICATIONS AND USAGE---------------------------ABILIFY is an atypical antipsychotic indicated as oral formulations for the: Treatment of schizophrenia (1.1) • Adults: Efficacy was established in four 4-6 week trials and one maintenance trial in patients with schizophrenia (14.1) • Adolescents (ages 13-17): Efficacy was established in one 6-week trial in patients with...

We retrospectively identified 14 elderly patients with a history of partial seizures who received levetiracetam (LEV) monotherapy. Patients began LEV either as first line therapy (n=5) or were converted to LEV monotherapy (n=9) after failing prior antiepileptic medications (AEDs). Thirteen patients continued on LEV monotherapy for at least 6 months. One patient was lost to follow-up. Eight pati...

The purpose of this prospective study was to evaluate the efficacy and safety of adefovir dipivoxil with or without ongoing lamivudine in decompensated lamivudine-resistant chronic hepatitis B patients. Forty-six hepatitis B e antigen (HBeAg)-positive patients with decompensated liver function and lamivudine-resistant hepatitis B virus (HBV) were assigned to adefovir dipivoxil monotherapy (n=18...

Objective. To evaluate the efficacy of infliximab (IFX) monotherapy versus infliximab-azathioprine sequential treatment in Crohn's disease (CD) patients. Methods. Patients newly diagnosed with CD using IFX as induction therapy were enrolled. After 6 times of IFX infusions, they were divided into IFX monotherapy group and IFX-AZA sequential therapy group. Clinical remission rates were assessed a...

Objective: To assess the efficacy and safety of use midazolam as monotherapy, compared to associated hydroxyzine for minimum moderate sedation children in dental offices, using data obtained from clinical trials. Material Methods: A systematic review protocol was developed registered on PROSPERO (CR42020208633). An electronic search carried out Pubmed, Lilacs, Science Direct, Open Gray, Web Sci...

Many patients with hypertension require 2 or more drug classes to achieve their blood pressure (BP) goal. We compared antihypertensive medication treatment patterns and BP control between who initiated combination therapy versus monotherapy. identified adults enrolled in a US integrated healthcare system 2008 2014. Patient demographics, clinical characteristics, medication, were extracted from ...

Bipolar disorder is a brain illness that causes mood, energy, and ability to function variations. patients have extreme emotional states often occur over period of days weeks, referred as mood episodes. Manic/hypomanic (abnormally cheerful or angry mood) depressed (sad episodes are classified. People with bipolar frequently periods neutral mood. can live long productive lives if they treated. T...

OBJECTIVES Data are scarce on the long-term efficacy of lopinavir/ritonavir monotherapy for the maintenance of HIV suppression. Four years of results of patients randomized to monotherapy in the Only Kaletra (OK) pilot clinical trial are presented. PATIENTS AND METHODS Twenty-one HIV-infected patients with suppressed HIV replication (<50 copies/mL) for at least 6 months and without previous f...