In this work, an improved single-column chromatographic (ISCC) separation process is proposed. The term `improved' refers to both conceptual and physical modifications compared to the available single-column processes, including a novel fraction collection scheme and allowing overlapped peaks from adjacent cycles. Also the fraction collection mechanism was modified in order to facilitate online...

The application of reduction rules to any Petri net may assist in its analysis as its reduced version may be significantly smaller while still retaining the original net’s essential properties. Reset nets extend Petri nets with the concept of a reset arc, allowing one to remove all tokens from a certain place. Such nets have a natural application in business process modelling where possible can...

The advantages of the digital PCR technology are already well documented until now. One way to achieve better cost efficiency of the technique is to use it in a multiplexing strategy. Droplet digital PCR platforms, which include two fluorescence filters, support at least duplex reactions and with some developments and optimization higher multiplexing is possible. The present study not only show...

OBJECTIVES To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage. DESIGN Meta-analysis of 24 randomised controlled trials (almost 66 000 participants). INTERVENTION Aspirin compared with placebo or no treatment, for a minimum of one year. MAIN OUTC...

This study gives strategies for estimating the modified Allan variance (MVAR), and formulas for computing the equivalent degrees of freedom (edf) of the estimators. A thirddifference formulation of MVAR leads to a tractable formula for edf in the presence of power-law phase noise. The effect of estimation stride on edf is shown. First-degree rational-function approximations for edf are derived,...

I n the early 1970s, when recombinant DNA technology became available, scientists exercised a healthy amount of caution. Within just a few years, as effective laboratory safety rules were established, it became clear that DNA recombinant organisms posed no greater risk than any other biotechnology, including particularly agricultural biotechnology. This evident lack of special risk is what has ...

The era of metabolic engineering has begun, but there is only limited knowledge about metabolic fluxes and how they are regulated in plants. Particular challenges are the non-linearities between enzyme abundances, metabolite concentrations and metabolic fluxes, and the existence of metabolic networks that provide multiple routes between many important metabolites. NMR offers the means to distin...

BACKGROUND Eukaryote cells are suggested to arise somewhere between 0.85~2.7 billion years ago. However, in the present world of unicellular organisms, cells that derive their food and metabolic energy from larger cells engulfing smaller cells (phagocytosis) are almost exclusively eukaryotic. Combining these propositions, that eukaryotes were the first phagocytotic predators and that they arose...

Agricultural biotechnology--GMOs--has a huge positive impact on farming and farmers but remains controversial among the skeptical public. Curious but anxious consumers, driven by scare stories and pseudo-science provided by anti-GMO activists, seek accurate and authoritative answers to their questions. Here, I address a sample of such queries directed to me from the public, including the ubiqui...

Endpoint detection is very important undertaking on the side of getting a good understanding and figuring out if a plasma etching process is done in the right way, especially if the etched area is very small (0.1%). It truly is a crucial part of supplying repeatable effects in every single wafer. When the film being etched has been completely cleared, the endpoint is reached. To ensure the desi...