The process of new drug development consists of several stages; after identifying potential candidate compounds, preclinical studies using animal models link the laboratory and human clinical trials. Among many steps in preclinical studies, toxicology and safety assessments contribute to identify potential adverse events and provide rationale for setting the initial doses in clinical trials. Ge...

By treating error probability law as a parameter of interest, location and scale as nuisance parameters in location-scale model, this paper suggests that modified profile likelihood (MPL), considered as quasi-likelihood function of the error probability law, be used for its selection. This model selection method is proved to be consistent and achieves minimax rate optimality. Simulations show i...

We introduce a model for prediction the behavior of electrodes which modified withcarbon nanotubes in a polymer medium. These kinds of polymer composites aredeveloped in recent years, and experimental data for its percolation threshold isavailable. We construct a model based on percolation theory and fractal dimensionsand using experimental percolation threshold for calculating the moments of c...

: The CIECAM97s and its revision, as a colour appearance model, were applied for a series of fabrics with different colours and depths to explain their colour appearance coordinates in similar viewing conditions. The results show that due to some modifications which expand the scale, the modified model has improved capadilities in calculating chroma. Besides, the calculations were simpler for t...

A modified lattice Boltzmann model based on the two-dimensional, nine-velocity lattice-Bhatnagar-Gross-Krook fluid is presented for axisymmetric flows. A spatially and temporally varying source term is incorporated into the evolution equation for the momentum distribution function on a two-dimensional Cartesian lattice. The precise form of the source term is derived through a Chapman-Enskog ana...

In spite of the great successes of General Relativity (GR) it has not got the status of a complete theory of gravity. To modify GR there are motivations coming from its quantum aspects, string theory, astrophysics and cosmology. For example, cosmological solutions of GR contain Big Bang singularity, and Dark Energy as a cause for accelerated expansion of the Universe. This initial cosmological ...

We previously presented a single-channel speech enhancement technique called the Modified Phase Opponency (MPO) model. The MPO model is based on a neural model called the Phase Opponency (PO) model. The efficacy of the MPO model was demonstrated on speech signals corrupted by additive white noise. In the present work, we extend the MPO model to perform efficiently on speech signals corrupted by...

A novel segmentation scheme for noisy image is proposed. According to the analysis of wavelet denoising method and multiscale geometric analysis techniques, an improved wavelet denoising algorithm combined with multiscale geometric analysis is presented in this paper first. Due to the isotropic nature of wavelet transform, 2D image details are not well represented in wavelet transform, which re...

The distributed Maxwell-slip model provides a convenient way to describe the presliding friction behavior. The modified single-state Maxwell-slip (MMS) model is proposed with the main benefit to require two concentrated parameters only when describing the smooth hysteresis of the presliding friction. The model is rate-independent at both, saturated and unsaturated hysteresis, and is consistent ...