Neuropeptide FF (NPFF) modulates the opioid system by exerting functional anti-opioid activity on neurons, the mechanism of which is unknown. By using a model of SH-SY5Y cells, we recently postulated that anti-opioid activity likely takes place upstream from the signaling cascade, suggesting that NPFF receptors could block opioid receptors by physical interaction. In the present study, fluoresc...

BACKGROUND Opioid analgesics are the most effective drugs for the treatment of moderate to severe pain. However, they also produce several adverse effects that can complicate pain management. The μ opioid (MOP) receptor, a G protein-coupled receptor, is recognized as the opioid receptor type which primarily mediates the pharmacological actions of clinically used opioid agonists. The morphinan c...

We discuss two issues in using mixtures of polynomials (MOPs) for inference in hy-brid Bayesian networks. MOPs were proposed by Shenoy and West for mitigating theproblem of integration in inference in hybrid Bayesian networks. First, in definingMOP for multi-dimensional functions, one requirement is that the pieces where thepolynomials are defined are hypercubes. In this pap...

The bispecific monoclonal antibody (Bi-MAb) HRS-3/AP-1 was developed by somatic hybridization of the 2 mouse hybridoma cell lines HRS-3 and AP-1, which produce monoclonal antibodies with reactivity against the Hodgkin's- and Reed-Sternberg cell-associated CD30 antigen and alkaline phosphatase, respectively. After an active incubation with alkaline phosphatase, respectively. After an active incu...

The main goal of this paper is to describe inference in hybrid Bayesian networks (BNs) using mixtures of polynomials (MOP) approximations of probability density functions (PDFs). Hybrid BNs contain a mix of discrete, continuous, and conditionally deterministic random variables. The conditionals for continuous variables are typically described by conditional PDFs. A major hurdle in making infere...

1 This paper analyzes the vocative truncation pattern in Korean from the viewpoint ofMessage2 Oriented Phonology (MOP: Hall et al. 2016), which capitalizes on the idea that sound patterns 3 are governed by a principle that makes message transfer effective. In the traditional naming 4 pattern, Korean first names consist of a generation marker and a unique portion, and the or5 der between these t...

The aim of this study was to investigate effects of mop handle height on electromyographic (EMG) activities of the shoulder muscles and perceived exertion for the shoulder area during floor mopping using a figure eight method. An experimental study with 13 cleaners was conducted using surface EMG and category ratio (CR-10) scale. EMG activity was recorded unilaterally from the upper trapezius, ...

To determine the effects and the underlying mechanism of diosgenin (DSG) and 5-methoxypsoralen (5-MOP), two main active components in the classical Chinese prescription Hu-Lu-Ba-Wan (HLBW), on insulin resistance, HepG2 cells were incubated in medium containing insulin. Treatments with DSG, 5-MOP, and their combination were performed, respectively. The result showed that the incubation of HepG2 ...

Odorant-binding proteins (OBPs), also named pheromone-binding proteins when the odorant is a pheromone, are essential for insect olfaction. They solubilize odorants that reach the port of entry of the olfactory system, the pore tubules in antennae and other olfactory appendages. Then, OBPs transport these hydrophobic compounds through an aqueous sensillar lymph to receptors embedded on dendriti...

BACKGROUND To test the psychometric properties of the Persian version of Zarit Burden Interview (ZBI-12) in the Iranian population. METHODS After translating and cultural adaptation of the questionnaire into Persian, 100 caregiver spouses of Iran- Iraq war (1980-88) veterans with chronic spinal cord injury who live in the city of Mashhad, Iran, invited to participate in the study. The Persian...