The development of microneedles (MNs) assisted drug delivery technologies have been highly active for more than two decades. minimally invasive and self-administered MN technology bypasses many challenges associated with injectable systems, by delivering the therapeutic materials directly into dermal ocular space allowing release ingredient in a sustained or controlled manner. Different types M...

In this work, the effects of carbon content and manganese sulfide addition on the microstructure and mechanical properties of copper steel parts have been studied. Steel powder mixture containing 2%Cu and different graphite contents with and without MnS additions were compacted, sintered and forged to almost full density. Forged samples, with near theoretical densities, were tested for tensile,...

Background: This study investigates the effects of melatonin on the sperm quality, the level of antioxidant enzymes (TAC) and malondialdehyde (MDA) after the combination of swimming exercise and nandrolone decanoate (DECA). Materials and Methods: Two groups of male Wistar rats were treated for eight weeks as follows; group A consist of: CO (control), Sham, N (DECA), S (swimming) and NS (DECA pl...

Ocular motoneuron firing rate is linearly related to conjugate eye position with slope K above recruitment threshold theta. Within the population of ocular motoneurons K increases as theta increases. These differences in firing rate between motoneurons might be determined either by the intrinsic properties of the motoneurons, or by differences in synaptic input to them, or by a combination of t...

The influence of Ca treatment, Mg treatment and Ca–Mg combined on the inclusions in 45MnVS non-quenched tempered steel were studied present work. After melting experiment, a hot rolling test was carried out ingot. Additionally, composition, quantity morphology samples analyzed by automatic scanning electron microscopy (ASPEX) an energy dispersive X-ray spectrometer connected to microscope (SEM-...

Robert E. Druzinsky Dept. of Physiology Northwestern University Chicago, IT.. 60611 w. Zev Rymer Dept. of Physiology and Biomedical Engineering Northwestern University Chicago, IT.. 60611 Using a quasi-realistic model of the feedback inhibition ofmotoneurons (MNs) by Renshaw cells, we show that weak inhibition is sufficient to maximally desynchronize MNs, with negligible effects on total MN act...

Monodispersed hollow spindle-like nanosphere (HS-NS) and tetrapod nanorod (TP-NR) MnS nanocrystals are obtained via a facile template-free hydrothermal process. The MnS nanocrystals are used as supercapacitor materials and they exhibit high performances. The TP-NR nanocrystals show a higher specific capacitance of 704.5 F g(-1) compared to the HS-NS nanocrystals, and both show higher values com...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from the brain stem nuclei and ventral roots of the spinal cord, leading to fatal paralysis. Currently, there are no effective therapies for ALS. Increasing evidence indicates that neuroinflammation plays an important role...