INTRODUCTION Post-intubation tracheal stenosis (PITS) continues to be challenging in terms of diagnosis, management and prevention. Recurrence is common because of excessive granulation tissue formation and an insidious process of scar contracture. Topical application of mitomycin-C (MMC) as an adjuvant treatment for endoscopic management of stenosis has shown good results. The authors aimed to...

BACKGROUND AND OBJECTIVES Fanconi anemia (FA) cells are characteristically hypersensitive to bifunctional alkylating agents, notably mitomycin C (MMC), causing increased programmed cell death (PCD). FA cells also have abnormalities in mitochondrial function. We hypothesized that the abnormalities in PCD are mitochondrially mediated. We examined mitochondrial function in FA cells, comparing the ...

PURPOSE To determine the long-term antiscarring effect of ilomastat treatment after experimental glaucoma filtration surgery (GFS). METHODS In a randomized, prospective, masked-observer study, 21 New Zealand White rabbits underwent modified GFS. The animals were allocated to receive either intraoperative mitomycin-C (MMC) at a concentration of 0.2 mg/mL or postoperative subconjunctival inject...

Background. To compare the efficacy of needle revision with 5-fluorouracil (5-FU) and mitomycin C (MMC) on dysfunctional filtration blebs shortly after trabeculectomy. Methods. It is a prospective randomized study comparing needle revision augmented with MMC or 5-FU for failed trabeculectomy blebs. Results. To date 71 patients (75 eyes) have been enrolled, 40 eyes in the MMC group and 35 in the...

AIM To evaluate topical mitomycin C (MMC) chemotherapy in the treatment of conjunctival melanoma and primary acquired melanosis with atypia. METHODS In a phase I clinical trial, 10 patients with conjunctival melanoma and/or primary acquired melanosis with atypia were treated with topical MMC 0.04% four times daily. Four patients were given MMC for 28 days as a primary treatment. Six patients ...

The Modular Multilevel Converter (MMC) topology is becoming an attractive solution for HVDC and FACTS systems. MMC structures are composed from several hundreds to thousands of half-bridge converters. Such large numbers of power switches and electrical nodes introduce important computational difficulties in electromagnetic transient (EMT) type programs. This becomes particularly more complex fo...

Maximum margin criterion (MMC) is a well-known method for feature extraction and dimensionality reduction. However, MMC is based on vector data and fails to exploit local characteristics of image data. In this paper, we propose a two-dimensional generalized framework based on a block-wise approach for MMC, to deal with matrix representation data, that is, images. The proposed method, namely, bl...

possibly involved in the regulation of sleep. The present study was designed to investigate the role of brain monoamines in the sleep disorder of MMC-dosed rats and attempts to elucidate the MMC-induced sleep disorder from the standpoint of changes in the concentrations of brain monoamines. MMC was administered orally to 12 Sprague-Dawley male rats 8 weeks age at a dose of 15 mg MMC/kg body wei...

Amplification of DNA in vivo occurs in intracellular environments characterized by macromolecular crowding (MMC). In vitro Polymerase-chain-reaction (PCR), however, is non-crowded, requires thermal cycling for melting of DNA strands, primer-template hybridization and enzymatic primer-extension. The temperature-optima for primer-annealing and extension are strikingly disparate which predicts pri...

Molecular hybridization studies were carried out by using a [3H]complementary DNA (cDNA) probe to compare the endogenous type C retrovirus of rhesus monkeys (MMC-1) with other known retroviruses and related sequences in various primate DNAs. The genomic RNA of the endogenous type C retrovirus of stumptail monkeys (MAC-1) was found to be highly related to the MMC-1 cDNA probe, whereas the other ...