OBJECTIVE Around one-third of patients with bipolar I disorder (BD-I) experience mixed episodes, characterized by both mania and depression, which tend to be more difficult and costly to treat. Atypical antipsychotics are recommended for the treatment of mixed episodes, although evidence of their efficacy, tolerability, and cost in these patients is limited. This study evaluates, from a UK Nati...

Boron arsenide $(c\text{\ensuremath{-}}\mathrm{BAs})$ is at the forefront of research on ultrahigh thermal conductivity materials. We present a Raman scattering study isotopically tailored cubic boron single crystals for 11 isotopic compositions spanning range from nearly pure $c\text{\ensuremath{-}}^{10}\mathrm{BAs}$ to $c\text{\ensuremath{-}}^{11}\mathrm{BAs}$. Our results provide insights ef...

Case presentation: A 5-year-old female with a history of neurodevelopmental delay, hypersomnolence, seizures, and feeding disturbance, presented complex movement disorder. Clinically, there was abnormal facial features, hypotonia, the patient mixed hyperkinetic disorder, consisting chorea, dystonia, myoclonus, hand stereotypies. The presence generalized interposed those movements, resembled “st...

Objectives: We have demonstrated that allogeneic bone marrow transplant (BMT) with low-dose total body irradiation (TBI) and anti-CD40L mAb without lymphoablative treatment achieved durable mixed chimerism and permanent donor-specific tolerance. Also, allogeneic mixed chimerism induced by anti-CD40L-containing regimen overcomes both alloand autoimmunity in NOD mice. BXSB mice with a lymphoproli...

Schizoaffective disorder is characterized by the presence of symptoms of both schizophrenia and a major mood disorder. The coexistence of these symptoms can be difficult to manage, and these patients are generally treated with antipsychotics as well as mood stabilizers and/or antidepressants. Additionally, no established treatment guidelines exist for this disorder. This review describes the co...

Background: Mixed gonadal dysgenesis is a rare congenital and challenging condition, characterized mainly by 45,X/46,XY karyotype mosaicism, asymmetrical development various internal external genital anatomy. Because of frequent disorder higher risk germ cell neoplasia, management these patients complex requires multidisciplinary approach.Case: We present mixed patient diagnosed with gonadoblas...

this paper highlights a variety of personality disorders in individuals with eating disorder and also emphasizes the importance of identifying clinically meaningful eating disorders subtypes based on concurrent personality disorder. the relationship between personality disorders and eating disorders is an important issue as this association has implications for assessment and treatment. differe...

objective: obsessive-compulsive disorder at clinical levels has elevated symptoms that result in deteriorated psycho-social functions. this study was aimed to examine the effectiveness of cognitive analytic therapy on symptoms severity of obsessive-compulsive disorder. methods: this exploratory empirical study was a clinical trial that used quasi-experimental design to systemically investigate ...