The effects of treatment with various doses of carcinostatic agents on tumor growth have been studied. In animal experiments. treatment with low concentrations of nitrogen mustard N-oxide resulted in an early death of mh:e bearing Ehrlich ascites carcinoma and an increase in the number of circulating Yoshida sarcoma cells. The growth of subcutaneously implanted Yoshida sarcoma was stimulated af...

The neural crest cells showed a specific sensitivity to mitomycin C, and the neural crest cells in mice treated with mitomycin C were not stained by hematoxylin and eosin. Reports have already been made on the distribution of the neural crest cells in mice embryos of early stage in regard to the characteristics of the staining ability by mitomycin C (Nozue and Kirino 1973 ; Nozue 1973 ; Nozue 1...

The use of histone deacetylase inhibitors has been proposed as a promising approach to increase the cell killing effect of DNA damage–inducing drugs in chemotherapy. However, the molecular mechanism of their action remains understudied. In the present article, we have assessed the effect of the histone deacetylase inhibitor sodium butyrate on the DNA damage response induced by the crosslinking ...

In Erwinia carotovora subsp. carotovora 71, the induction of pectin lyase (Pnl), the bacteriocin carotovoricin (Ctv), and cellular lysis (Lss) requires a RecA function. We obtained mutants wherein a pleiotropic defect, i.e., the lack of induction with mitomycin C, is not restored by the recA+ DNA. From a genomic library of strain 71, a cosmid (pAKC280) that restored induction of Pnl, Ctv, and L...

Objectives: To determine the efficacy, best indications, and regimens of intravesical adjuvant instillations in case of non–muscle-invasive bladder tumours. Methods: The authors analyse the most significant articles of the literature to draw recommendations. Results: The three main factors that appear to determine a patient’s ultimate prognosis are tumour size at presentation, the grade, and th...

Two human mesothelioma xenograft lines, BG and ES, serially passaged in athymic mice, were studied to determine the efficacy of alpha-interferon in this type of tumor. Treatment began after progressive tumor growth was established. Recombinant human alpha-interferon-2a (Roferon- A) was given by s.c. injection, at a site distant from the tumor, at a dose of 2 x 10(5) IU 5 days per wk for 5 wk. M...

PURPOSE: We studied the effects of exposure to mitomycin C and 5-Fluorcuracil to human RPE cultures, in growth inhibition and citoxicity. METHODS: 1) Growth inhibition: RPE cultures (3.000 cells/well) were exposed to different concentrations of mitomycin C and 5-Fluorouracil, and cell viability (MTT test) was evaluated 48h, 72h and 96h after. 2) Citotoxicity: RPE cultures (10.000 cells/well) we...

PURPOSE To compare histologically the action of Mitomycin C and that of Clobetasol propionate for surgical wound healing in rats. METHODS A circular skin fragment was surgically removed from 57 Wistar rats. Twenty-two animals were treated with Mitomycin C with topical medication in a single dose, 22 with Clobetasol propionate with a cream medication once a day for 15 days and 13 did not recei...

purpose: to assess the short-term effect of mitomycin-c (mmc) 0.02% on endothelial cell density and morphology after photorefractive keratectomy (prk) in patients with moderate myopia. methods: forty-two eyes of 21 participants with moderate myopia (range, -4.0 to -8.0 d) underwent prk with mmc 0.02% for 40 seconds. specular microscopy was performed preoperatively and repeated 6 months after su...