A defect in lymphocyte function could be responsible for persistent infection by the equine infectious anemia virus. The number of lymphocytes bearing surface immunoglobulin, as detected by immunofluorescence, and lymphocyte response to mitogens were the same in uninfected and equine infectious anemia-infected animals. A defect in T or B lymphocyte numbers or ability to respond to stimuli was n...

35 Method: ICR-CD1 old female mice were maintained in group (n=8) or isolated (n=10) during one month. Then, a group of isolated mice (n=5) was submitted to a 4-weeks hydrotherapy treatment. Peritoneal leukocytes were obtained and macrophages and lymphocytes chemotaxis, and lymphoproliferation in absence (basal) or presence of the mitogens Lipopolyssaccharide and Concanavalin A were analyzed. M...

ABSTRACT. It is known that under the influence of specific mitogens, sensitized T-lymphocytes produce № 199 cytokines in culture medium, which are divided into two fractions: F1 and F2. The first (F1) them determines pathogenesis AD children this fraction produced during immunopathological reactions, second (F2) responsible for immunological parameters activation T-system immunity their regulat...

Abstract Extracellular High Mobility Group Box 1 (HMGB1) is a prototypic damage-associated molecular pattern (DAMP). While homeostatic level of extracellular HMGB1 may be beneficial for immune defense, tissue repair and regeneration, excessive linked to chronic inflammation inflammatory diseases. This prompts an intriguing question: How does healthy body control the HMGB1? Here we have identifi...

Cell cycle progression is a tightly controlled process. To initiate cell division, mitogens trigger a number of early signals that promote the G(0)-G(1) transition by inducing cell growth and the activation of G(1) cyclins. Activation of cyclin E/cdk2 (cyclin-dependent kinase 2) at the end of G(1) is then required to trigger DNA synthesis (S phase entry). Among the early signals induced by mito...

Considering growing evidence indicating that hepatitis C virus (HCV) replicates in lymphoid cells, establishment of a reliable and sensitive method for detection of HCV in these cells may provide means for monitoring the infection and the efficacy of sterilizing antiviral therapy. In this study, conditions for ex vivo augmentation and detection of the HCV genome in peripheral blood mononuclear ...

Extracts of seeds of 21 bean cultlvars were screened for hemagglutinating specifity and for mitogenic activity. Four types could be distinguished in different beans, two of which are mitogens. Two lectin fractions (α and b) were isolated from each of the four bean types. Their MW were estimated by exclusion chromatography and component sugars by paper chromatography. Hemagglutinating activity, ...