نتایج جستجو برای: mitochondrial respiratory chain complex i
تعداد نتایج: 2265450 فیلتر نتایج به سال:
Complex I is the first enzyme of the respiratory chain in both the bacterial and the mitochondrial inner membranes. The mitochondrial enzyme from the aerobic yeast Yarrowia lipolytica has a molecular weight close to 1 MDa and contains at least 42 subunits. Complex I in all species exhibits an L-shape with two arms of similar length, one embedded in the membrane (membrane arm) and the other reac...
Complex I (NADH-ubiquinone oxidoreductase) in the respiratory chain of mitochondria and several bacteria functions as a redox-driven proton pump that contributes to the generation of the protonmotive force across the inner mitochondrial or bacterial membrane and thus to the aerobic synthesis of ATP. The stoichiometry of proton translocation is thought to be 4 H(+) per NADH oxidized (2 e(-)). He...
Taurine is a ubiquitous sulfur-containing amino acid found in high concentration in most tissues. Because of its involvement in fundamental physiological functions, such as regulating respiratory chain activity, modulating cation transport, controlling inflammation, altering protein phosphorylation and prolonging lifespan, taurine is an important nutrient whose deficiency leads to severe pathol...
To elucidate the molecular mechanisms of the protective action of stigmatellin (an inhibitor of complex III of mitochondrial electron transport chain, mtETC) against the heavy metal-induced cytotoxicity, we tested its effectiveness against mitochondrial membrane permeabilization produced by heavy metal ions Cd²(+), Hg²(+), Cu²(+) and Zn²(+), as well as by Ca²(+) (in the presence of P(i)) or Se ...
Background. Mitochondrial respiratory chain (RC) disorders are a growing group of with large variety clinical presentations ranging from well-defined syndromes to nonspecific manifestations, such as failure thrive, exercise intolerance and seizures.Objective. To describe the clinical, biochemical, histochemical spectrum 38 Egyptian patients clinically suspected havingmitochondrial RC disorders....
Complement component 1 Q subcomponent-binding protein (C1QBP; also known as p32) is a multi-compartmental protein whose precise function remains unknown. It is an evolutionary conserved multifunctional protein localized primarily in the mitochondrial matrix and has roles in inflammation and infection processes, mitochondrial ribosome biogenesis, and regulation of apoptosis and nuclear transcrip...
The complexes of the electron transport chain associate into large macromolecular assemblies, which are believed to facilitate efficient electron flow. We have identified a conserved mitochondrial protein, named respiratory supercomplex factor 1 (Rcf1-Yml030w), that is required for the normal assembly of respiratory supercomplexes. We demonstrate that Rcf1 stably and independently associates wi...
The etiology of mammalian senescence is suggested to involve the progressive impairment of mitochondrial function; however, direct observations of age-induced alterations in actual respiratory chain function are lacking. Accordingly, we assessed mitochondrial function via high-resolution respirometry and mitochondrial protein expression in soleus, quadricep, and lateral gastrocnemius skeletal m...
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