نتایج جستجو برای: mir 122

تعداد نتایج: 60190  

Journal: :Molecular medicine reports 2014
Binggui Zhang Rongqi Wang Jinghua Du Jingya Niu Rui Zhang Shunjiang Xu Xuemin Niu Qingfu Zhang Yuemin Nan

Mounting evidence indicates that dysregulated microRNAs (miRNAs) are important in the etiology and pathogenesis of steatohepatitis. However, the functions of miRNAs in the pathophysiological process of non-alcoholic steatohepatitis (NASH) are poorly understood. In this study, C57BL/6J mice were fed a methionine-choline‑deficient (MCD) diet for eight weeks in order to induce hepatic steatohepati...

Objective(s): Gallic acid (GA) is a highly effective antioxidant, which its beneficial effects are well known, but its impact on expression of microRNAs (miRs) following hepatic ischemia-reperfusion (I/R) is not well recognized. Therefore, the current research was designed to specify the beneficial effect of GA on miRs (122 and 34a), liver functional tests, and histopathological alterations bey...

2015
Richard Kia Lorna Kelly Rowena L. C. Sison-Young Fang Zhang Chris S. Pridgeon James A. Heslop Pete Metcalfe Neil R. Kitteringham Melissa Baxter Sean Harrison Neil A. Hanley Zoë D. Burke Mike P. Storm Melanie J. Welham David Tosh Barbara Küppers-Munther Josefina Edsbagge Philip J. Starkey Lewis Frank Bonner Ernie Harpur James Sidaway Joanne Bowes Stephen W. Fenwick Hassan Malik Chris E. P. Goldring B. Kevin Park

Emerging hepatic models for the study of drug-induced toxicity include pluripotent stem cell-derived hepatocyte-like cells (HLCs) and complex hepatocyte-non-parenchymal cellular coculture to mimic the complex multicellular interactions that recapitulate the niche environment in the human liver. However, a specific marker of hepatocyte perturbation, required to discriminate hepatocyte damage fro...

2013
Darong Yang Binbin Xue Xiaohong Wang Xiaoyan Yu Nianli Liu Yimin Gao Chen Liu Haizhen Zhu

Many chronic hepatitis C virus (HCV)-infected patients with current therapy do not clear the virus. It is necessary to find novel treatments. The effect of 2-octynoic acid (2-OA) on HCV infection in human hepatocytes was examined. The mechanism of 2-OA antiviral activity was explored. Our data showed that 2-OA abrogated lipid accumulation in HCV replicon cells and virus-infected hepatocytes. It...

2010

MicroRNAs (miRNAs) are non-coding small RNAs that regulate eukaryotic gene activity at the post-transcriptional level by a process termed miRNA gene suppression. MicroRNA-122 (miR-122) is predominantly expressed in human liver cells and recent studies indicated that miR-122 promotes Hepatitis C Virus (HCV) replication and translation through physical interaction with two tandem binding sites lo...

Journal: :Current opinion in lipidology 2012
Jennifer Sacco Khosrow Adeli

PURPOSE OF REVIEW MicroRNAs (miRNAs) regulate gene expression by binding to target mRNAs and control a wide range of biological functions. Recent reports have identified specific miRNAs as major regulators of fatty acid and cholesterol homeostasis. This review examines the biological function of various miRNAs and the emerging evidence linking specific miRNAs to critical pathways in lipid metab...

Journal: :PloS one 2015
Fatma Aboulnasr Sidhartha Hazari Satyam Nayak Partha K Chandra Rajesh Panigrahi Pauline Ferraris Srinivas Chava Ramazan Kurt Kyongsub Song Asha Dash Luis A Balart Robert F Garry Tong Wu Srikanta Dash

BACKGROUND HCV replication in persistently infected cell culture remains resistant to IFN-α/RBV combination treatment, whereas IFN-λ1 induces viral clearance. The antiviral mechanisms by which IFN-λ1 induces sustained HCV clearance have not been determined. AIM To investigate the mechanisms by which IFN-λ clears HCV replication in an HCV cell culture model. METHODS IFN-α sensitive (S3-GFP) ...

Journal: :Open Access Macedonian Journal of Medical Sciences 2022

Background: The identification of miRNAs that play a role in the regulation viral life cycle and its related liver illness opens door to development diagnostic biomarkers can categorize patients at higher risk for developing end-stage disease. This study was designed investigate hepatitis-induced chronic disease (CLD) Egyptian population, as well their potential possible hepatitis virus infecti...

Journal: :Molecular medicine reports 2013
Lilin Wang Wei Tang Shirong Yan Long Zhou Tao Shen Xiuqing Huang Lin Dou Mo Wang Songlin Yu Jian Li

MicroRNAs (miRNAs) are small non-coding RNAs that are important in the pathogenesis of multiple diseases and, therefore, may represent a novel class of targets for therapeutic intervention. However, like the majority of oligonucleotide-based strategies, there are obstacles to their clinical application, including poor cellular uptake due to the low permeability of the cell membrane to negativel...

2017
Anastasia Hyrina Andrea D. Olmstead Paul Steven Mel Krajden Edward Tam François Jean

In patients with chronic hepatitis C virus (HCV) infection, viral hijacking of the host-cell biosynthetic pathways is associated with altered lipid metabolism, which contributes to disease progression and may influence antiviral response. We investigated the molecular interplay among four key regulators of lipid homeostasis [microRNA (miR)-122, miR-24, miR-223, and proprotein convertase subtili...

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