Objective(s): Non-small cell lung cancer (NSCLC) has become a serious global health problem in the 21st century, and tumor proliferation and metastasis are the leading causes of death in patients  with lung cancer. The present study aimed to verify the function of miR-96 and miR-96 in relation to competing with endogenous RNA regulatory network in NSCLC progression inc...

downs syndrome (ds), or trisomy 21, is the most common genetic cause of cognitive impairment and congenital heart defects in the human population. to date, the contribution of micrornas (mirnas) in ds has not been investigated. bioinformatic analyses demonstrate that human chromosome 21 (hsa21) harbors five mirna genes mir-99a, let-7c, mir-125b-2, mir-155 and mir-802. mirna expression profiling...

Background: MicroRNAs are small noncoding RNAs that regulate gene expression and involve in many cellular and physiological mechanisems. Recent studies have revealed that dysregulation of microRNAs might contribute to autoimmune disorders such as multiple sclerosis. Based on these findings, we examined the potential role of miR-320 isoforms, miR-320-3p and miR-320-5p, in the context of autoimmu...

Objective(s): Although low-dose radiotherapy (RT) that involves low collateral damage is more suitable for hepatocellular carcinoma (HCC) than traditional high-dose RT, but to achieve satisfactory therapeutic effect with low-dose RT, it is necessary to sensitize HCC cells to irradiation. This study was aimed to determine whether radiosensitivity of HCC cells can be enhanced using miR-26b by tar...

Vitamin A and its derivatives, particularly retinol, slow both chronological photo-induced aging processes. Retinol reduces the appearance of wrinkles decrease skin firmness elasticity by protecting against collagen elastin fiber changes. In addition to retinol’s rejuvenating benefits through direct transcriptional activation, recent studies also suggest an epigenetic regulation micro-RNAs (miR...

Abstract Background Rheumatoid arthritis (RA) is the most common chronic autoimmune connective tissue disease. However, early RA difficult to diagnose due lack of effective biomarkers. This study aimed identify new biomarkers and mechanisms for disease progression at transcriptome level through a combination microarray bioinformatics analyses. Methods Microarray datasets synovial in or osteoart...