This study was undertaken to develop a functional model of otitis media with effusion (OME) in the pig (Sus scrofa), with the purpose of investigating the origin of lymphocytes populating the middle ear during the course of an inflammatory process. The relevance of the model to the human condition of OME is to a large extent dependent on the anatomical and physiological similarities between the...

Introduction Frequent visits to rule out acute otitis media or to verify resolution of middle ear fluid accumulation occupy a substantial number of pediatric office appointments and emergency department visits, many of which are unnecessary. Clinical studies and experience have shown that acute otitis media is difficult to diagnose by symptoms alone and is frequently overdiagnosed by parents of...

BACKGROUND Otitis media with effusion (OME) is one of the most frequently met pathologies in small children. Long-term persistence of the liquid in the middle ear cavity correlates with the impairment in speech acquisition and poor results in school. AIM To evaluate the predictive value of impedancemetry in recovery of the normal middle ear status. METHODS 30 children (age 4 month-9 years) ...

OBJECTIVE To determine whether vitamin A supplementation administered in the preschool years can lower the risk of hearing loss in adolescence and adulthood. DESIGN Follow-up study of adolescents and young adults who, as preschool aged children in 1989, were enrolled into a cluster randomised, double blinded, placebo controlled trial of vitamin A supplementation. SETTING South central, rura...

PURPOSE OF REVIEW Otitis media is the most common bacterial infection among children, accounting for as many as 30 million office visits annually. Proper treatment has become critical as offending pathogens become increasingly resistant to antibiotics and the cost of managing the disorder has exceeded 3 billion dollars per year. However, data suggest that many practitioners still struggle with ...

Genetic susceptibility underlying otitis media (OM) remains to be understood. We show in this study that mutation in Phex gene predisposes the BALB/c-Phex(Hyp-Duk)/Y (abbreviated Hyp-Duk/Y) mice to OM, which occurs at post-natal day 21 (P21) with an average penetrance of 73%. The OM was identified by effusion in the middle ear cavity and/or thickening of middle ear mucosae, and was characterise...

1 Assistant Professor of ENT Medical Sciences School Universidade Nacional de Assunção, ENT assistant physician. 2 Full Professor of ENT Medical Sciences School Universidade Nacional de Assunção, Chefe do Serviço. 3 Resident Physician Hospital General Universitário Gregorio Marañon Madrid. 4 Full Professor of Otorhinolaryngology Medical Sciences School Santa Casa de São Paulo. Hospital de Clíni...

OBJECTIVES Wideband reflectance (WBR) is a middle ear analysis technique that quantifies frequency-specific sound conduction over a wide range of frequencies. One shortcoming of WBR is that there is limited normative data, particularly for pediatric populations and children with middle ear pathology. The goals of this study were to establish normative WBR data for early school-aged children; to...