This paper introduces a new approach to fitting a linear regression model to symbolic interval data. Each example of the learning set is described by a feature vector, for which each feature value is an interval. The new method fits a linear regression model on the mid-points and ranges of the interval values assumed by the variables in the learning set. The prediction of the lower and upper bo...

DNA replication is spatially and temporally regulated during S-phase. DNA replication timing is established in early-G1-phase at a point referred to as timing decision point. However, how the genome-wide replication timing domains are established is unknown. Here, we show that Rif1 (Rap1-interacting-factor-1), originally identified as a telomere-binding factor in yeast, is a critical determinan...

The purpose of this study was to investigate the effects of supplementation with amino acids and vitamins on health conditions in unhealthy older people. One bedridden inpatient group (n = 10; mean age, 79.8 ± 8.5 y) and one outpatient group (n = 9; mean age, 72.9 ± 12.2 y) participated in this study. A mixture supplementation with amino acids containing arginine (500 mg/day), glutamine (600 mg...

Gene identity by descent (IBD) is a fundamental concept that underlies genetically mediated similarities among relatives. Gene IBD is traced through ancestral meioses and is defined relative to founders of a pedigree, or to some time point or mutational origin in the coalescent of a set of extant genes in a population. The random process underlying changes in the patterns of IBD across the geno...

Existing research argues that the muscular male body ideal, often promoted in the media, is associated with male body dissatisfaction and increasingly problematic attempts to attain unrealistic body shape by young males. The present study sought to examine the influence of ‘‘lad magazines”, a highly popular media sector over the last decade, and also the role of dating, or relationship, status,...

We present a simple Monte Carlo method for estimating the age of the most recent common ancestor (MRCA) of a sample of DNA sequences. We show that Templeton's (1993) estimator of the age of the MRCA based on the maximum number of nucleotide differences between two sequences in a sample is inaccurate, and we demonstrate the new method by reanalyzing a sample of DNA sequences from human Y chromos...

A feasibility design study was undertaken to assess the requirements of a mid-infrared echelle spectrograph (MIRES) with a resolving power of 120,000 and its associated mid-infrared adaptive optics (MIRAO) system on the Thirty-Meter Telescope. Our baseline design incorporates a 2Kx2K Si:As array or array mosaic for the spectrograph and a 1Kx1K Si:As array for the slit viewer. Various tradeoffs ...

Branching process in random environment (BPRE) are a generalization of GaltonWatson processes where the reproduction law is picked randomly in an i.i.d manner in each generation. In the supercritical case, the population Zn either explodes (with a positive probability) or becomes extincted. We are interested in the event when the process Zn takes positive but bounded values for large times n. W...

We report on the generation of narrowband carrier-envelope phase stable mid-infrared (MIR) pulses between 10 and 15 μm. High pulse energies and narrow bandwidths are required for the selective nonlinear excitation of collective modes of matter that is not possible with current sources. We demonstrate bandwidths of <2% at 12.5 μm wavelength through difference frequency generation between two nea...