Microvesicles (diameter ca 200 nm) from the cell-free supernatant of U87MG human glioblastoma cell caused platelet aggregation and coagulation in a manner identical with that previously shown for the intact cells. Both activities were inhibited by dansylarginine-N-(3-ethyl-1 .5pentanediyl) amide (DAPA). confirming the thrombindependent nature of both activities. The specific activities per micr...

Cell communication is well known to rely on direct contacts or on secreted factors that bind to receptors located on the surface of their target cells. In addition to this classical pathway, recent results have shown that cells produce microvesicles that contain functional DNA, RNA and proteins that can be directly transferred to recipient cells. This induces proliferation, differentiation or c...

Background. It is known that the number of polymorphonuclear leukocytes increases with development periodontitis. However, their role in pathogenesis chronic periodontitis has not been fully defined.
 Aim. To study pathogenetic periodontitis, realized by microvesicles and aggression factors (metalloproteinases, myeloperoxidase, calprotectin, lipocaine 2).
 Material methods. 30 patient...