Currently the “pandemic” of diabetes mellitus is noted. The incidence and prevalence diabetic retinopathy, most common microvascular complications diabetes, are exponentially growing due to increased life expectancy in many parts world. increasing number people suffering from retinopathy not only highlights medical issues, but also an economic burden, representing a social challenge. It extreme...

Although HLA alleles are associated with type 1 diabetes, association with microvascular complications remains controversial. We tested HLA association with complications in multiplex type 1 diabetes families. Probands from 425 type 1 diabetes families from the Human Biological Data Interchange (HBDI) collection were analyzed. The frequencies of specific HLA alleles in patients with complicatio...

OBJECTIVE To develop and validate a risk engine that calculates the risks of macro- and microvascular complications in type 2 diabetes. RESEARCH DESIGN AND METHODS We analyzed pooled data from two clinical trials on 1,748 Japanese type 2 diabetic patients without diabetes complications other than mild diabetic retinopathy with a median follow-up of 7.2 years. End points were coronary heart di...

D iabetes currently affects about 5% of world’s populations, and its prevalence is rapidly increasing particularly in elderly subjects. Because over 80% of all diabetic subjects have type 2 diabetes, the increase in the number of individuals with diabetes implies an epidemic of type 2 diabetes. Diabetes is associated with hyperglycemia-specific microvascular complications. Furthermore, macrovas...

Inflammation drives arterial, venous and microvascular thrombosis. Chronic inflammation contributes to arterial thrombotic complications, whereas acute inflammation drives venous thrombosis and microvascular thrombosis. Mechanistically, inflammation modulates thrombotic responses by upregulating procoagulants, downregulating anticoagulants and suppressing fibrinolysis. The inflammatory response...

Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the ...

With recent advances in the instrumentation and with increased expertise the results of microvascular surgery are getting better. Complications though, cannot be completely avoided. This paper gives a brief introduction to the possible complications at various stages of free tissue transfer. With careful planning and execution and vigilant postoperative care the overall success rate can be impr...

PURPOSE Obesity is a major public health concern in the United States, affecting nearly 79 million people. There have been promising results performing microvascular breast reconstruction in patients with obesity; however, the definition of obesity is often poorly defined or does not extend above a body mass index (BMI) of 35. Our goal was to examine outcomes of microvascular breast reconstruct...

OBJECTIVE A protective effect of residual beta-cell function on microvascular complications of type 1 diabetes has been suggested. Our aim was to retrospectively evaluate the association of fasting plasma C-peptide values with micro- and macrovascular complications. RESEARCH DESIGN AND METHODS We recruited a clinic-based cohort of 471 type 1 diabetic patients born after 1945 and cared for in ...

The development of skin manifestations of diabetes affects up to two thirds of patients with both types 1 and 2 diabetes mellitus. Cutaneous manifestations of diabetes occur because of the microvascular complications of diabetes, impaired wound healing, and other yet undetermined mechanisms. This article summarizes the most frequent skin findings in patients with diabetes, and proposes treatmen...