Microsporidia comprise a large phylum of fungal-related pathogens that have been studied since the time of Louis Pasteur, who in 1870 found that they were responsible for silkworm disease that was decimating the silkworm industry [1,2]. These obligate intracellular microbes are ubiquitous, but have remained enigmatic because of the difficulties of culturing them in the lab. In the 1990s there w...