Background: Indeterminate Colitis (IC) is diagnosed after colectomy when macroscopic and microscopic features were not suficient to allow a deinite diagnosis of either the classical types of Ulcerative Colitis (UC) or Crohn’s disease (CD). Epidemiological data from some series have reported that IC is diagnosed in between 9% and 20% of colectomy specimens. Aim: To determine the prevalence of IC...

BACKGROUND/AIMS Bone marrow-derived mesenchymal stem cells (BM-MSCs) have shown beneficial effects in experimental colitis models, but the underlying mechanisms are not fully understood. We investigated the long-term effects of BM-MSCs, particularly in mice with chronic colitis. METHODS Chronic colitis was induced by administering 3% dextran sulfate sodium (DSS) in a series of three cycles. B...

Inflammatory bowel disease (IBD) is a group of conditions that affect the gastrointestinal system. IBD consists of autoimmune diseases that attack the GI mucosa, resulting in inflammation of the gut wall. For this discussion, we will be focusing on ulcerative colitis (UC) and Crohn’s disease (CD). The main differences between the two are that ulcerative colitis mainly involves the large intesti...

Inflammatory bowel disease (IBD) is a group of conditions that affect the gastrointestinal system. IBD consists of autoimmune diseases that attack the GI mucosa, resulting in inflammation of the gut wall. For this discussion, we will be focusing on ulcerative colitis (UC) and Crohn’s disease (CD). The main differences between the two are that ulcerative colitis mainly involves the large intesti...

Inflammatory bowel disease (IBD) is a group of conditions that affect the gastrointestinal system. IBD consists of autoimmune diseases that attack the GI mucosa, resulting in inflammation of the gut wall. For this discussion, we will be focusing on ulcerative colitis (UC) and Crohn’s disease (CD). The main differences between the two are that ulcerative colitis mainly involves the large intesti...

Colitis can occur from viral or bacterial infections, ischemic insult, or autoimmune disorders; most notably Ulcerative Colitis and the colonic variant of Crohn's Disease - Crohn's Colitis. Acute colitis may present with abdominal pain and distention, malabsorption, diarrhea, hematochezia and mucus in the stool. We are beginning to understand the complex interactions between the environment, ge...

Inflammatory bowel disease (IBD) is a group of disorders that are characterized by chronic, uncontrolled inflammation in the intestinal mucosa. Although the aetiopathogenesis is poorly understood, it is widely believed that IBD stems from a dysregulated immune response towards otherwise harmless commensal bacteria. Chemokines induce and enhance inflammation through their involvement in cellular...