Background & AimsAlthough type 2 innate lymphoid cells (ILC2s) were originally found to be liver-resident lymphocytes, the role and importance of ILC2 in liver injury remains poorly understood. In current study, we sought determine whether is an important regulator hepatic ischemia/reperfusion (IRI).MethodsILC2 deficient mice (ICOS-T or NSG) genetically modified ILC2s used investigate murine IR...

Background & AimsLiver regeneration is a repair process in which metabolic reprogramming of parenchymal and inflammatory cells plays major role. Monoacylglycerol lipase (MAGL) ubiquitous enzyme at the crossroad between lipid metabolism inflammation. It converts monoacylglycerols into free fatty acids metabolizes 2-arachidonoylglycerol arachidonic acid, being thus source pro-inflammatory prostag...

Sickle cell disease (SCD) is an inherited hemolytic disorder, defined by a point mutation in the β-globin gene. Stress conditions such as infection, inflammation, dehydration, and hypoxia trigger erythrocyte sickling. Sickled red blood cells (RBCs) hemolyze more rapidly, show impaired deformability, increased adhesive properties to endothelium. In proinflammatory, pro-coagulative environment wi...

The study is designed to evaluate the effect of aqueous extract P. lanceolata plant, as well know drug CCl4 on formation micronucleus in vivo 48 female albino mice. In mice were separated into eight groups treated intraperitoneally for seven day first group Negative control, second positive control( 0.02%), third (250 mg/kg), fourth (500 fifth (CCl4 0.02%) plus sixth seventh mg/kg) and eighth 0...

Rice germ is an abundant source of ferulic acid, which known for its anti-oxidant activity. This study aimed to evaluate the regulatory effects fermented rice extracts on hepatic glucose metabolism in C57BL/KsJ-db/db mice. was with Lactobacillus plantarum and extracted 30% ethanol (RG_30E) or 50% (RG_50E). Mice were fed modified AIN-93 diets containing acid 8 weeks. RG_50E significantly reduced...

Abstract Lipophagy, the selective engulfment of lipid droplets (LDs) by autophagosomes for lysosomal degradation, is critical to and energy homeostasis. Here we show that transfer protein ORP8 located on LDs mediates encapsulation autophagosomal membranes. This function independent its transporter activity achieved through direct interaction with phagophore-anchored LC3/GABARAPs. Upon lipophagy...

A growing number of long noncoding RNAs (lncRNAs) have emerged as vital metabolic regulators. However, most human lncRNAs are nonconserved and highly tissue specific, vastly limiting our ability to identify lncRNA regulators (hLMRs). In this study, we established a pipeline putative hLMRs that metabolically sensitive, disease relevant, population applicable. We first progressively processed mul...

Inosine 5′-monophoaphate (IMP) is a food additive that promotes serious lipohyperplasia in the liver of C57/KsJ-db/db (db/db) mice. Thus, IMP taken orally by healthy mice might also damage their health. To date, how affects health after being animals still unclear. Therefore, we investigated C57BL/6J affected intake. Our data revealed administered 255 μM daily via oral gavage for 4 months cause...

Abstract The fibrinogen protein is composed of three subunits encoded for by the genes Fga, Fgb, and Fgg. This trimer a main component blood clots. Irregular clotting contributes to low pressure during septic shock, which eventually leads death from total system organ failure. A previously published data set finds Fgg be dysregulated sepsis in serum both wildtype (WT) toll-like receptor 4 (TLR4...

P. vermicola is an opportunistic pathogen of human and animals. To estimate the pathogeneses P.vermicola in mice infected orally I/P with 1x108 CFU/ml).The histopathological changes at 24 hrs showed infiltration inflammatory cells apoptosis hepatocytes liver, around a congested blood vessel interstitial tissue kidney; lung revealed congestion vessels, alveolar emphysema; intestine appeared mono...