نتایج جستجو برای: mice bax and bcl 2 genes real time pcr brain

تعداد نتایج: 17613575  

Journal: :Environmental Toxicology 2021

Colorectal cancer (CC) is an important human malignancy with high related death worldwide. The chemotherapy using doxorubicin hydrochloride one of the most common therapeutic methods. However, drug resistance lowers treatment efficacy in CC patients. combination therapies seem to be more promising by taking advantage synergistic effects. present study aimed evaluate a new strategy enhance antic...

2012
Sara Soleimani Asl Mohammad Hassan Farhadi Kazem Moosavizadeh Ali Samadi Kuchak Saraei Mansoure Soleimani Seid Behnameldin Jamei Mohammad Taghi Joghataei Alireza Samzadeh-Kermani Hamed Hashemi-Nasl Mehdi Mehdizadeh

OBJECTIVE 3,4-methylenedioxymethamphetamine (MDMA) is an illicit, recreational drug that causes cellular death and neurotoxicity. This study evaluates the effects of different doses of MDMA on the expression of apoptosis-related proteins and genes in the hippocampus of adult rats. MATERIALS AND METHODS In this expremental study,a total of 20 male Sprague Dawley rats (200-250 g ) were treated ...

Journal: :Chinese journal of integrative medicine 2011
Hao Li Lin-lin Cai Jian-gang Liu Long-tao Liu Jie Guan Ming-fang Liu Jia Hu Yun Wei

OBJECTIVE To observe the effect of early intervention using extract of Huannao Yicong Decoction (, HYD) on the pathological picture of hippocampus, neurocyte apoptosis, and associated regulatory genes in β-amyloid precursor protein (APP) transgenic mice model of dementia. METHODS Sixty APP695(V7171) transgenic mice were randomly divided into four groups of 15. The model group was treated with...

Asaad Azarnezhad, Batool Hashemibeni Mansour Salehi, Mehdi Nikbakht Dastjerdi Mohammad Kazemi, Zahra Babazadeh,

Background: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in cancer. As methylation is a reversible modification, agents capable of reversing an abnormal methylation status should help to combat cancer. 5-Aza-CdR is a DNA methyl-transferase inhibitor. The present study aimed to evaluate the effect of 5-Aza-CdR on the proliferation of human pancreatic cancer ...

ژورنال: :پاتوبیولوژی مقایسه ای 0
سمانه شبانی، پژمان مرتضوی . .

آپوپتوزیس به مرگ برنامه ریزی شده ژنتیکی سلول گفته می شود که در بسیاری از شرایط فیزیولوژیک و پاتولوژیک نقش مهمی ایفا میکند. پروتئین  bax ﺑـﻪ ﻋﻨـﻮان ﯾـﮏﭘﺮوﺗﺌﯿﻦ ﮐﻠﯿﺪی در آﭘﻮﭘﺘﻮز اﻟﻘﺎء ﺷﺪه ﺗﻮﺳﻂ ﻋﻮاﻣـﻞ ﻣﺨﺘﻠـﻒ در ﻣﺴﯿﺮ داﺧﻠﯽ آﭘﻮﭘﺘﻮز  عمل نموده و 2-bcl  ﯾﮏ اﺛـﺮ آﻧﺘـﯽ آﭘﻮﭘﺘﻮﺗﯿـﮏ در ﭘﺎﺳﺦ ﺑﻪ ﻣﺤﺮک ﻫﺎی ﻣﺨﺘﻠﻒ آﭘﻮﭘﺘﻮز از ﻃﺮﯾﻖ ﺟﻠﻮﮔﯿﺮی از رﻫﺎ شدن سیتوکرومc  از میتوکندری، دارد. در مطالعه­ی حاضر اثر  دزهای مختلف ...

Journal: :Tropical Journal of Pharmaceutical Research 2022


 Purpose: To determine the effect of ursolic acid (UA) on diabetes-induced cognitive defect, as well its mechanism action in streptozotocin (STZ)-induced diabetic rats.
 Methods: A rat model diabetes was established by administration STZ. The rats received UA via gastric perfusion for 56 successive days. Learning and memory functions were assessed using Morris water maze. Superoxide ...

2014
HUAN WANG LIANCHENG ZHU JIAN GAO ZHENHUA HU BEI LIN

Available evidence on the proliferation-promoting effect of HE4 remains controversial, and few studies have been carried out on the molecular mechanism of chemoresistance mediated by HE4. The aim of the present study was to investigate the influence of exogenous recombinant HE4 protein on proliferation and resistance to carboplatin in ovarian cancer cells. The human ovarian cancer cell line (SK...

2013
Korakot Nganvongpanit Waranee Pradit Siriwadee Chomdej

This study examined the relationship between days of hip luxation and the expression of various mRNA. Twenty-six articular cartilages were used in the experiment: 3 samples were from normal dogs and 23 samples were collected from the femoral heads of hips that had been luxated for different lengths of time. Ten mRNA, including nonapoptotic genes (AGG, COL2A1, MMP-3, HAS-1, HAS-2, and TIMP-1) an...

Journal: :International journal of clinical and experimental medicine 2015
Shuyuan Zhao Hui Yu Nan Du

OBJECTIVE This study aims to explore the effect of doxorubicin interventional chemotherapy on rabbit VX2 renal transplantation carcinoma and its mechanism. METHODS Thirty healthy New Zealand white rabbits were chosen to establish VX2 renal transplantation carcinoma models. The experimental rabbits were randomly divided into three groups with 10 rabbits in each group. The rabbits in the contro...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Thomas A Buchholz Amit K Garg Nitin Chakravarti Bharat B Aggarwal Francisco J Esteva Henry M Kuerer S Eva Singletary Gabriel N Hortobagyi Lajos Pusztai Massimo Cristofanilli Aysegul A Sahin

PURPOSE Molecular factors involved in apoptosis may affect breast cancer response to chemotherapy. Herein, we studied the nuclear factor kappaB (NF-kappaB)/bcl-2 pathway to determine whether or not activation of this antiapoptotic pathway was associated with a poor response of human breast cancer to anthracycline-based neoadjuvant chemotherapy. EXPERIMENTAL DESIGN We studied 82 human breast c...

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