BACKGROUND Tissue-specific monoallelic silencing of the RYR1 gene has been proposed as an explanation for variable penetrance of dominant RYR1 mutations in malignant hyperthermia (MH). We examined the hypothesis that monoallelic silencing could explain the inheritance of an MH discordant phenotype in some instances. METHODS We analysed parent-offspring transmission data from MH kindreds to as...

We prepared magnesium hydroxide (MH) nanoparticles, and investigated their effect when combined with dissolved carteolol on the bioavailability and intraocular pressure (IOP)-reducing effect of carteolol. The carteolol was solved in saline containing additives (0.5% methylcellulose, 0.001% benzalkonium chloride, 0.5% mannitol; CRT-solution). MH nanoparticles were prepared by a bead mill method ...

This work presents a simple mobility scheme for IP-based networks, termed the “anchor chain” scheme. The scheme combines pointer forwarding and caching methods. Every mobile host (MH) is associated with a chain of anchors that connects it to its home agent. Each anchor defines the location of the MH at a certain degree of accuracy. The accuracy is increased along the chain until the attachment ...

s Caries Res 2009;43:179–244 187 with MH were prepared by sectioning and polishing. Cross-sectional Vickers hardness of the 600  m thick enamel sections was measured across MH-affected and apparently sound areas and mean hardness values analysed by one-way ANOVA. Subsequently these sections were lapped to 100 m and assessed using polarizing microscopy (PM) and transverse microradiography (TMR)...

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle triggered in susceptible individuals by inhalation anesthetics and depolarizing skeletal muscle relaxants. This syndrome has been linked to a missense mutation in the type 1 ryanodine receptor (RyR1) in more than 50% of cases studied to date. Using double-barreled Ca(2+) microelectrodes in myotubes expressing wild-type...

As of 1986 a laboratory for the diagnosis Malignant Hyperthermia (MH) was established at University Antwerp which since then served as national reference this rare anesthetic complication. Our unit is an accredited lab within network European Group and thus has had chance to attain solid practical expertise in disorder, well collaborate several multicentre studies on MH. The present review summ...

BACKGROUND Isolated systolic hypertension (ISH) is a major cardiovascular risk factor. The prevalence of ISH, isolated diastolic (IDH), and mixed hypertension (MH) and their association with lipid, inflammatory, and endothelial cell markers were assessed. METHODS A population sample from Haute-Garonne, France, was chosen. RESULTS Prevalence of ISH, IDH, and MH was 16%, 5%, and 16%, respecti...

THE MEDICAL HOME The Patient Centered Medical Home (PCMH) is an approach to providing comprehensive primary care for children, youth, and adults.1 PCMH facilitates partnerships with individual patients, their personal physicians, and family. In pediatrics, PCMH is usually referred to as the Patient and Family Centered Medical Home, or just the Medical Home (MH). The MH was named over 40 years a...

Screening for mental health (MH) and trauma-related needs among children and youth involved in child welfare (CW) services refers to broadly administering a brief measurement instrument and using scores to identify children and youth who demonstrate need for additional MH services. Based on review of the CW and MH literature and consultation with experts in the field, the CASAT team has designe...