نتایج جستجو برای: methyltransferase

تعداد نتایج: 22647  

Journal: :The Journal of biological chemistry 2009
Tsuneo Ferguson Jitesh A Soares Tanja Lienard Gerhard Gottschalk Joseph A Krzycki

Archaeal methane formation from methylamines is initiated by distinct methyltransferases with specificity for monomethylamine, dimethylamine, or trimethylamine. Each methylamine methyltransferase methylates a cognate corrinoid protein, which is subsequently demethylated by a second methyltransferase to form methyl-coenzyme M, the direct methane precursor. Methylation of the corrinoid protein re...

Journal: :American journal of physiology. Cell physiology 2000
N F Al-Baldawi J D Stockand O K Al-Khalili G Yue D C Eaton

Aldosterone increases Na(+) reabsorption by renal epithelial cells: the acute actions (<4 h) appear to be promoted by protein methylation. This paper describes the relationship between protein methylation and aldosterone's action and describes aldosterone-mediated targets for methylation in cultured renal cells (A6). Aldosterone increases protein methylation from 7.90 +/- 0.60 to 20.1 +/- 0.80 ...

Journal: :International journal of clinical and experimental medicine 2015
Rongju Sun Jiahong Liu Bo Wang Lingyun Ma Xiaojiao Quan Zhixiang Chu Tanshi Li

In this study, the relationship between CpG island methylation and smoking and DNA methyltransferase in the occurrence and development of lung adenocarcinoma was explored by detecting p16 promoter methylation status. Protein and mRNA levels of p16 were detected by immunohistochemistry and in situ hybridization assays. p16 gene promoter and exon 1 CpG island locus Hap II sites methylation status...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
E Kim J D Lowenson D C MacLaren S Clarke S G Young

L-Asparaginyl and L-aspartyl residues in proteins are subject to spontaneous degradation reactions that generate isomerized and racemized aspartyl derivatives. Proteins containing L-isoaspartyl and D-aspartyl residues can have altered structures and diminished biological activity. These residues are recognized by a highly conserved cytosolic enzyme, the protein L-isoaspartate(D-aspartate) O-met...

Journal: :The Biochemical journal 2003
Liu Yang Qi Mei Anna Zielinska-Kwiatkowska Yoshito Matsui Michael L Blackburn Daniel Benedetti Anton A Krumm Gerald J Taborsky Howard A Chansky

Covalent modifications of histone tails play important roles in gene transcription and silencing. We recently identified an ERG ( ets -related gene)-associated protein with a SET (suppressor of variegation, enhancer of zest and trithorax) domain (ESET) that was found to have the activity of a histone H3-specific methyltransferase. In the present study, we investigated the interaction of ESET wi...

2012
Myrna Candelaria Erick de la Cruz-Hernandez Lucia Taja-Chayeb Enrique Perez-Cardenas Catalina Trejo-Becerril Aurora Gonzalez-Fierro Alma Chavez-Blanco Ernesto Soto-Reyes Guadalupe Dominguez Jaenai E. Trujillo Jose Diaz-Chavez Alfonso Duenas-Gonzalez

BACKGROUND Down regulation of genes coding for nucleoside transporters and drug metabolism responsible for uptake and metabolic activation of the nucleoside gemcitabine is related with acquired tumor resistance against this agent. Hydralazine has been shown to reverse doxorubicin resistance in a model of breast cancer. Here we wanted to investigate whether epigenetic mechanisms are responsible ...

2013
Scarlet S. Shell Erin G. Prestwich Seung-Hun Baek Rupal R. Shah Christopher M. Sassetti Peter C. Dedon Sarah M. Fortune

DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely locus-specific mechanisms. Here, we identify a critical DNA methyltransferase in M. tuberculosis, which we term MamA. MamA creates N⁶-methyladenine in a six base pair recogniti...

Journal: :Nucleic acids research 1997
S Xu J Xiao J Posfai R Maunus J Benner

BssHII restriction endonuclease cleaves 5'-GCGCGC-3' on double-stranded DNA between the first and second bases to generate a four base 5'overhang. BssHII restriction endonuclease was purified from the native Bacillus stearothermophilus H3 cells and its N-terminal amino acid sequence was determined. Degenerate PCR primers were used to amplify the first 20 codons of the BssHII restriction endonuc...

Journal: :Nucleic acids research 2004
Ohad Fisher Rama Siman-Tov Serge Ankri

The DNA methylation status of the protozoan parasite Entamoeba histolytica was heretofore unknown. In the present study, we developed a new technique, based on the affinity of methylated DNA to 5-methylcytosine antibodies, to identify methylated DNA in this parasite. Ribosomal DNA and ribosomal DNA circles were isolated by this method and we confirmed the validity of our approach by sodium bisu...

2011
Tomasz P. Jurkowski Albert Jeltsch

The Dnmt2 enzymes show strong amino acid sequence similarity with eukaryotic and prokaryotic DNA-(cytosine C5)-methyltransferases. Yet, Dnmt2 enzymes from several species were shown to methylate tRNA-Asp and had been proposed that eukaryotic DNA methyltransferases evolved from a Dnmt2-like tRNA methyltransferase ancestor [Goll et al., 2006, Science, 311, 395-8]. It was the aim of this study to ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید