نتایج جستجو برای: methylguanine
تعداد نتایج: 2664 فیلتر نتایج به سال:
Alkylation of DNA at the O6-position of guanine is one of the most critical events leading to mutation, cancer, and cell death. The enzyme O6-methylguanine-DNA methyltransferase repairs O6-methylguanine as well as a minor methylated base, O4-methylthymine, in DNA. Mouse lines deficient in the methyltransferase (MGMT) gene are hypersensitive to both the killing and to the tumorigenic effects of ...
A number of trace nucleotides are reported to be present in ribonucleic acids from various sources. Cohn (I) and Davis and Allen (2) have described a nucleotide in yeast ribonucleic acids, the nucleoside of which has recently been identified as 5ribosyluracil.’ Littlefield and Dunn (3) have found small amounts of thymine, 2-methyladenine, N6-methyladenine2 (6methylaminopurine), and Ne-dimethyla...
Molecular alterations in glioblastoma have the potential to guide treatment. Here, we explore the relationship between temozolomide (TMZ) response and O(6)-methylguanine DNA methyltransferase (MGMT) status in brain tumor initiating cells (BTICs). Methylation, expression, and sensitivity were assessed in 20 lines; associations were evaluated by Fisher's exact test. Some BTICs were sensitive. Sen...
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