The title compound, C(20)H(32)N(2)O(2)S(2), has been synthesized by the reaction of α-methyl-sulfanylcyclo-dodeca-none and p-toluene-sulfonyl-hydrazine. In the crystal structure, the conformation of the non-benzenoid ring is [3333] and the methyl-sulfanyl group is in the α-side exo position. The mol-ecules are linked by inter-molecular N-H⋯S hydrogen bonds.

The revised MicroScan Dried Overnight Gram-Positive Identification panel was evaluated for its efficacy at identifying Enterococcus species in comparison with conventional biochemical tests. Supplemental testing of ampicillin-susceptible Enterococcus faecium for motility and the ability to acidify methyl-alpha-D-glucopyranoside helped recognize E. gallinarum and increased the accuracy of the pa...

Toxaemia of Pregnancy-Hans and Kopelman MEDICALOURL 739 1960) and a central effect (Gillespie et alc., 1962) may play some part. Agar et al. (1958) discussed the underlying theories of pre-eclamptic hypertension production in view of mecamyl-amine and the ganglion-blocking hypotensive agents being ineffectual in controlling this condition. Recently, Senior et al. (1963) have suggested that 5-hy...

Intermittent claudication is an occasional side effect of beta-adrenergic blockade' but clinical details are lacking. Beta-blocking agents may exacerbate intermittent claudication in patients with severe peripheral arterial insufficiency.2 The following cases suggest that they may also provoke claudication in patients with previouslv asymptomatic peripheral arterial disease. Case 1 A man aged 5...

The effect of antiadrenergic treatment with methyldopa was studied in 17 patients with established essential hypertension who were subdivided with respect to age in a group younger (n = 10; mean age, 47 +/- 2.4 (SEM) years; and a group older than 60 years of age (n = 7, mean age, 67 +/- 2.8 SEM). The fall in arterial pressure was associated with a significant (p less than 0.05) decrease in card...

A multicenter, randomized double-blind study of 6 months' duration was performed in 540 patients (average age 54 years, 57% male) with mild-to-moderate essential hypertension to determine the relative effects on quality of life of cilazapril, atenolol, and nifedipine retard. Quality of life was assessed by using both a self-administered and an interviewer-administered questionnaire; the assessm...

One hundred and eighty three hypertensive pregnant women were randomly assigned to antihypertensive treatment with oxprenolol (96 women) or methyldopa (87 women). Control of hypertension was equivalent in both treatment groups, and in 64 (35%) cases hydralazine had to be added to the treatment to achieve the therapeutic goal (diastolic blood pressure below 85 mm Hg). Five perinatal deaths occur...

Twenty-six patients suffering from mild to moderate hypertension were randomly assigned to one of two antihypertensive regimens, and active therapy continued for six weeks. The first regimen consisted of TRASICOR (oxprenolol) 80 mg twice daily plus HYGROTON (chlorthalidone) 20 mg once daily, while the second regimen consisted of methyldopa 250 mg thrice daily plus HYGROTON 20 mg once daily. The...