A simple rapid, economically accurate and precise reverse phase high performance liquid chromatographic method was developed for the estimation of Metformin HCl (MET) and Pioglitazone (PIO) in pure and in pharmaceutical dosage forms. A Hypersil BDS C18 column (250x4.6mm, 5μ) was used with a mobile phase containing a mixture of Acetonitrile and Sodium dihydrogen phosphate buffer in the ratio of ...

PURPOSE In this work a numerical method, based on the use of spectrophotometric data coupled to partial least squares (PLS) regression and net analyte preprocessing combined with classical least square (NAP/CLS) multivariate calibration, is reported for the simultaneous determination of metformin hydrochloride (MET), gliclazide (GLZ) and pioglitazone hydrochloride (PIO) in synthetic samples and...

ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. metformin can either protect or damage cells by activating amp-activated protein kinase (ampk) and its downstream factors so, it has a dual role in the cerebral ischemia context, bu...

Biodegradable polyesters, such as the poly(lactic-co-glycolic acid) (PLGA), have been extensively used a polymer matrix for entrapping variety of active compounds. In this study, physicochemical phenomena that control mass transport mechanism hydrophilic compounds released from PLGA microspheres were identified. This study aims to produce and characterize loaded with metformin hydrochloride (MH...

results there was no statistical difference between the 2 groups with respect to the recurrence rate (p > 0.05). although the recurrence interval was longer for the metformin group, this increase was not statistical significant (p > 0.05). furthermore, tumor recurrence had no correlation with sex or the grade of the tumors. conclusions according to our findings, it seems that metformin has no c...

Abstract Obesity is a state of abnormal or excessive fat accumulation. in horses increases the risk developing variety health issues such as: insulin dysregulation (ID), reduced athleticism, colic, reproductive performance, laminitis, endotoxaemia, diabetes mellitus , hyperlipaemia, impaired thermoregulation, pituitary pars intermedia dysfunction, and osteochondrosis. significant welfare issue ...