This reaction allows for new olefins to be synthesized and used as raw materials in polymers, perfumes, drugs and agrochemical industrial products, also serving as the starting point for more complex organic molecules. Catalytic systems are based mainly on the metals W, Mo, Re and Ru. The metal-alkylidenes synthesized by Schrock, [Mo(CHR)(NAr)(OR f ) 2 ], Grubbs, [Ru(CHR)(PCy 3 ) 2 Cl 2 ], Herr...

A new extension of the Birch-Cope sequence is described which allows the efficient enantioselective construction of highly functionalized, fused bicarbocyclic structures with an all-carbon quaternary stereocenter in two steps. The two step sequence includes a cross metathesis between a terminal alkene and a polarized alkene followed by an intramolecular Rauhut-Currier reaction with a trialkylph...

Various macrocycles were prepared in one step by a novel ring-expansion method using olefin metathesis.

Key words (‒)-exiguolide - macrolide marine natural product macrocyclization ring-closing metathesis transannular cyclization

R ing-closing olefin metathesis (RCM) is an effective method for the formation of cyclic alkenes (1). Recently, the aromatization of RCM products has emerged as a topic of intensive investigation (2). In this context, a variety of regiocontrolled protocols have been developed for the synthesis of diverse heteroaromatic compounds, such as pyridines, pyridazines, pyrroles, quinolines, and furans ...

The reaction between disulfides and phosphines generates a reversible disulfide metathesis process.

This work presents an examination of the selective functionalization norbornadiene through nitrile oxide 1,3-dipolar cycloaddition/ring-opening metathesis (ROM)/cross-metathesis (CM) protocols. Functionalization commercially available provided novel bicyclic scaffolds with multiple stereogenic centers. The synthesis involved cycloadditions, subsequent ROM formed cycloalkene-fused isoxazoline an...

The ring closing olefine metathesis in protic solvents using a new ruthenium benzylidene complex is described.