background: the sentinel lymph node (sln) is defined as the first chain node in the lymphatic basin that receives primary lymphatic flow. if the sln is negative for metastatic disease, then other nodes are expected to be disease-free. sln techniques have been extensively applied in the staging and treatment of many tumors, including melanoma, breast and vulvar cancers. this study aims to evalua...

Metastatic skin cancer is a rare complication of internal malignancies.  Patients who develop cutaneous metastases rarely present with a zosteriform distribution.  Herein, we describe a 65-year-old woman with a prior history of breast cancer in whom zosteriform metastases developed along her left T8-9 abdominal dermatomes.

Background: Malignant melanoma is a highly metastatic cutaneous cancer and typically refractory to chemotherapy. Deregulated apoptosis has been identified as a major cause of cancer drug resistance, and upregulated expression of the inhibitor of apoptosis protein melanom, an inhibitor of apoptosis (ML-IAP) is frequent in melanoma. Methods: Based on the conclusion that ML-IAP expression contribu...

Viola odorata as a medical herb is used in liver disorders and relieving cancer pain. In the present study, the cytotoxic, antioxidant, and anti-metastatic properties of Viola odorata hydro-alcoholic extract (VOE) were investigated in 4T1 breast cancer model. After treatment of 4T1 breast cancer cells with VOE, cell viability was measured by MTT assay. The implanted mice were treated with diffe...

Background: A soluble form of HER-2/neu extracellular domain (sHER-2) is reported to be released in the sera of metastatic breast cancer patients. Objective: To measure the level of sHER-2 in sera of 115 breast cancer patients. Methods: Serial samples of 27 patients with metastasis, 18 non-metastatic patients, 15 patients in stage 0/I and 14 patients with accompanying benign breast disease were...

Viola odorata as a medical herb is used in liver disorders and relieving cancer pain. In the present study, the cytotoxic, antioxidant, and anti-metastatic properties of Viola odorata hydro-alcoholic extract (VOE) were investigated in 4T1 breast cancer model. After treatment of 4T1 breast cancer cells with VOE, cell viability was measured by MTT assay. The implanted mice were treated with diffe...

metastatic skin cancer is a rare complication of internal malignancies.  patients who develop cutaneous metastases rarely present with a zosteriform distribution.  herein, we describe a 65-year-old woman with a prior history of breast cancer in whom zosteriform metastases developed along her left t 8-9 abdominal dermatomes.

ILC represents ∼15% of all breast cancers (BC). Clinical, histological and molecular differences between BC non-special type support the idea as a separate entity. Unfortunately, evidence on treatment efficacy for is often lacking. We aimed to map out lack documentation representation patients with in clinical drug trials (CT), investigating gene expression profiles (GEPs) screening programs (M...

We compared a non-metastasising sarcoma cell population with three related populations of increasing metastatic potential. The metastatic cells in vitro exhibited a significantly reduced incidence of actin stress fibres but enhanced motility and chemotaxis. We also investigated gene expression underlying progression to a metastatic phenotype by performing a microarray analysis of the four sarco...

The aim of the present study was to investigate the status of oxidative stress in the serum of patients affected with cancer breast. Changes in the levels of total antioxidant capacity (TAC), uric acid, malondialdehyde (MDA), nitric oxide (nitrite/nitrate), cupper and iron were measured in serum of patients affected by non-metastatic as well as metastatic cancer breast. Significant decrease in ...