OBJECTIVE The authors present a profile of panic disorder based on and generalized from the effects of acute and chronic hyperventilation that are characteristic of the respiratory panic disorder subtype. The review presented attempts to integrate three premises: hyperventilation is a physiological response to hypercapnia; hyperventilation can induce panic attacks; chronic hyperventilation is a...

abstract hypotonia is a serious neurologic problem in neonatal period. although hypotonia is a nonspecific clinical finding but it is the most common motor disorder in the newborn. the objective of this study was to determine the frequency of neonatal hypotonia then to ascertain of the most common causes methods this cross –sectional prospective study was carried out on the 3281 term infants ho...

Both an arterial blood gas and a basic metabolic panel are necessary to determine a patient’s acid-base status. Analysis of a patient’s acid-base disorder includes identification of the primary disorder, calculation of the anion gap (AG), evaluation for the presence of excess acid or base, comparison of the expected and actual compensation, and explanation of the cause of each identified acid-b...

Background : personalized approach considering the effectiveness and safety of medication is main goal contemporary psychopharmacotherapy. Knowing special characteristics any given drug allows a practitioner to choose tactic meeting needs particular patient. The aim this narrative review was summarize data about use Brexpiprazole in pharmacotherapy different mental disorders. Method using keywo...

Polycystic ovarian syndrome (PCOS), also known as SteinLeventhal syndrome, is a common gynecological disorder characterized by hypergonadotrophism, hirsutism, obesity, oligomenorrhea and commonly associated with infertility. PCOS is a complex clinical picture and presents a multifaceted etiology related to imbalance of the hypothalamic-pituitary-adrenal (HPA) axis, thyroid involvement and metab...

Biotinidase deficiency is an inherited metabolic disorder that, if untreated, can result in neurological and cutaneous symptoms. If treated with the vitamin biotin, individuals with the disorder can markedly improve, but still may have some irreversible problems if therapy is delayed. If treated at birth, biotin therapy can prevent the development of symptoms as indicated by long-term outcomes....

background: diabetes mellitus is a serious public health problem worldwide and particularly in developing countries. in algeria, this metabolic disorder occurs with a wide variety or atypical forms that linked to multiple risk factors including local habits and traditions. this study aimed to determine the impact of risk factors (metabolic syndrome, social, cultural, physical activity, family h...

Neurologic regression in a previously healthy child may be caused by metabolic or neurodegenerative disorders, many of which have no definitive treatment. We report a case of a previously healthy 8-year-old boy who presented with a month-long history of waxing and waning encephalopathy and acute regression, followed by seizures. Evaluation for a metabolic disorder revealed methylmalonic acidemi...

Obstructive sleep apnoea (OSA) is a prevalent sleep disorder characterized by upper airway obstruction during sleep, resulting in intermittent breathing pauses despite effort, reduced blood oxygen saturation, hypoxia and arousals. With prevalence in the general population estimated at 17–24% of men and 5–9% of women (Young et al. 1993; Bixler et al. 1998, 2001), OSA has been linked to the key c...

Overhydrated hereditary stomatocytosis, clinically characterized by hemolytic anemia, is a rare disorder of the erythrocyte membrane permeability to monovalent cations, associated with mutations in the Rh-associated glycoprotein gene. We assessed the red blood cell metabolome of 4 patients with this disorder and showed recurrent metabolic abnormalities associated with this disease but not due t...