نتایج جستجو برای: mesothelioma

تعداد نتایج: 8141  

2012

Mesothelioma is a rare cancer of the thin lining that mainly covers the lungs and abdominal cavity. An average of 24 cases of mesothelioma was diagnosed per year in Ireland between 1994 and 2010 (Table 1), representing less than 0.2% of all invasive cancers. Over 5 times more frequently diagnosed in men than in women, the main risk factor for mesothelioma is asbestos, largely ascribed to work r...

Journal: :Chest 1988
T Pettersson B Fröseth H Riska M Klockars

Hyaluronic acid (HA) was determined with a radiometric assay in the serum and pleural fluid of 85 patients with pleural effusions, including 15 with malignant mesothelioma, 32 with other cancer, 31 with nonmalignant inflammatory diseases, and seven with congestive heart failure. With a cutoff level at 100 mg/L, the pleural fluid concentration of HA was raised in 73 percent of patients (11 of 15...

Journal: :European journal of cancer 2012
Sabine Siesling Jan Maarten van der Zwan Isabel Izarzugaza Jana Jaal Tom Treasure Roberto Foschi Umberto Ricardi Harry Groen Andrea Tavilla Eva Ardanaz

Rare thoracic cancers include those of the trachea, thymus and mesothelioma (including peritoneum mesothelioma). The aim of this study was to describe the incidence, prevalence and survival of rare thoracic tumours using a large database, which includes cancer patients diagnosed from 1978 to 2002, registered in 89 population-based cancer registries (CRs) and followed-up to 31st December 2003. O...

Journal: :Journal of the National Cancer Institute 2000
C T Yang L You C C Yeh J W Chang F Zhang F McCormick D M Jablons

BACKGROUND The p14(ARF) protein encoded by the INK4a/ARF locus promotes degradation of the MDM2 protein and thus prevents the MDM2-mediated inhibition of p53. Homozygous deletion of the INK4a/ARF locus is common in human mesothelioma and may result in the loss of p14(ARF) and the inactivation of p53. We designed this study to evaluate the biologic and potential therapeutic roles of p14(ARF) exp...

2015
Guntulu Ak Sandra C. Tomaszek Farhad Kosari Muzaffer Metintas James R. Jett Selma Metintas Huseyin Yildirim Emine Dundar Jie Dong Marie Christine Aubry Dennis A. Wigle Charles F. Thomas

INTRODUCTION We investigated the expression of microRNAs and mRNAs in pleural tissues from patients with either malignant pleural mesothelioma or benign asbestos-related pleural effusion. METHODS Fresh frozen tissues from a total of 18 malignant pleural mesothelioma and 6 benign asbestos-related pleural effusion patients were studied. Expression profiling of mRNA and microRNA was performed us...

Journal: :Annals of epidemiology 2011
Marty S Kanarek

PURPOSE There are different mineral classes of asbestos, including serpentines and amphiboles. Chrysotile is the main type of serpentine and by far the most frequently used type of asbestos (about 95% of world production and use). There has been continuing controversy over the capability of chrysotile asbestos to cause pleural and peritoneal mesothelioma. This review is to help clarify the issu...

2014
Soomin Ahn In Ho Choi Joungho Han Jhingook Kim Myung-Ju Ahn

BACKGROUND Malignant mesothelioma of the pleura is an aggressive tumor known to be associated with asbestos. Histological diagnosis of mesothelioma is challenging and is usually aided by immunohistochemical markers. METHODS During an 18-year period (1995-2012), 66 patients with pleural mesothelioma were diagnosed at the Samsung Medical Center in Seoul. We reviewed hematoxylin and eosin and im...

Journal: :Cancer letters 2016
M Betti A Aspesi A Biasi E Casalone D Ferrante P Ogliara L C Gironi R Giorgione P Farinelli F Grosso R Libener S Rosato D Turchetti A Maffè C Casadio V Ascoli C Dianzani E Colombo E Piccolini M Pavesi S Miccoli D Mirabelli C Bracco L Righi R Boldorini M Papotti G Matullo C Magnani B Pasini I Dianzani

BAP1 germline mutations predispose to a cancer predisposition syndrome that includes mesothelioma, cutaneous melanoma, uveal melanoma and other cancers. This co-occurrence suggests that these tumors share a common carcinogenic pathway. To evaluate this hypothesis, we studied 40 Italian families with mesothelioma and/or melanoma. The probands were sequenced for BAP1 and for the most common melan...

2010
Ser Can Jenet Nicho Nola J. Olsen Fraser Brims Ian M. Dick Arthur W. Musk Steven J. Skates

ownload kground: Malignant mesothelioma is an aggressive, almost uniformly fatal tumor, primarily caused by re to asbestos. Since the recent discovery that serum mesothelin is a sensitive and highly specific bior for mesothelioma, one of the key issues raised is whether mesothelin levels represent a useful screening r asbestos-exposed at-risk individuals. In this study, soluble mesothelin was d...

2015
Blake A. Jacobson Esther Z. Chen Shaogeng Tang Holly Sedgwick Belgum Joel A. McCauley Kristen A. Evenson Ryan G. Etchison Joe Jay-Dixon Manish R. Patel Ahmad Raza Ashok K. Saluja Jonathan D'Cunha Robert A. Kratzke

Malignant mesothelioma is a devastating disease with a poor prognosis for which there is a clear need for more successful therapeutic approaches. Triptolide, a diterpenoid triepoxide, is a highly effective agent against several cancer types in animal models. Owing to triptolide's poor solubility in water, a water-soluble analog, minnelide, was synthesized. Minnelide is a prodrug of triptolide a...

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