Background Proteolytic enzymes within venoms from different scorpion species belong to serine and metalloproteases class, and some isoforms of these enzymes show proteolytic activity over Aa and Bb subunits of fibrinogen [1-3]. Brotheas amazonicus is a non-lethal amazonian scorpion, belonging to a different group from Tityus genus, and there are scarce studies about its venom in literature [4]....

scorpionism is a known significant problem of medical and social importance in many tropical and subtropical regions including the middle east. in iran, highest prevalence of scorpion sting about 60% of all the stings has been reported from khuzestan province. among the 21,000 cases of reported scorpion stung patients, 12% were caused by h. lepturus, but contributed to 95% of all moralities in ...

scorpionism is a known significant problem of medical and social importance in many tropical and subtropical regions including the middle east. in iran, highest prevalence of scorpion sting about 60% of all the stings has been reported from khuzestan province. among the 21,000 cases of reported scorpion stung patients, 12% were caused by h. lepturus, but contributed to 95% of all moralities in ...

The scorpion has been extensively used in various pharmacological profiles or as food supplies. The exploration of scorpion venom has been reported due to the presence of recombinant peptides. rBmαTX14 is an α-neurotoxin extracted from the venom gland of the East Asian scorpion Buthus martensii Karsch and can affect ion channel conductance. Here, we investigated the functions of rBmαTX14 using ...

The non disulphide-bridged peptides (NDBPs) of scorpion venoms are attracting increased interest due to their structural heterogeneity and broad spectrum of biological activities. Here, two novel peptides, named AcrAP1 and AcrAP2, have been identified in the lyophilised venom of the Arabian scorpion, Androctonus crassicauda, through "shotgun" molecular cloning of their biosynthetic precursor-en...

scorpion venom toxicity is of major concern due to its influence on human activities and public health. we investigated the in-vitro process of cell death caused by two iranian scorpions odontobuthus doriae and bothutus salceyi venom on human cell lines. the aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...

Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain. Information on venom composition and the toxins present in these species is growing due to an interest in using bioactive toxins from spiders and scorpions for drug discovery purposes and for solving cr...

Scorpion venom, containing highly toxic, small polypeptides that diffuse rapidly within the patient, causes serious medical problems. Nanobodies, single-domain antigen-binding fragments derived from dromedary heavy-chain antibodies, have a size that closely matches that of scorpion toxins. Therefore these nanobodies might be developed into potent immunotherapeutics to treat scorpion envenoming....

BACKGROUND Clinically significant scorpion envenomation by Centruroides sculpturatus produces a dramatic neuromotor syndrome and respiratory insufficiency that often necessitate intensive supportive care. We hypothesized that a scorpion-specific F(ab')(2) antivenom would promptly resolve clinical symptoms in children with this syndrome. METHODS In a randomized, double-blind study, the efficac...