Bicontinuous lipid cubic mesophases are widely investigated as hosting matrices for functional enzymes to build biosensors and bio-devices due to their unique structural characteristics. However, the enzymatic activity within standard mesophases (in-meso) is severely hindered by the relatively small diameter of the mesophase aqueous channels, which provide only limited space for enzymes, and re...

Airway infection by the Gram-positive pathogen Streptococcus pneumoniae (Sp) leads to recruitment of neutrophils but limited bacterial killing by these cells. Co-colonization by Sp and a Gram-negative species, Haemophilus influenzae (Hi), provides sufficient stimulus to induce neutrophil and complement-mediated clearance of Sp from the mucosal surface in a murine model. Products from Hi, but no...

The technological infrastructures enabling the collection, processing, and trading of data have fuelled a rapid innovation governance models. We differentiate between macro, meso, micro level models, which correspond to major political blocks; societal-, industry-, or community systems, individual approaches, respectively. focus on meso-level coalesce around: (1) organisations prioritising thei...

We consider the problem of time-stepping/sampling for molecular and meso-scale particle dynamics. The aim of the work is to derive numerical time-stepping methods that generate samples exactly from the desired target temperature distribution. The numerical methods proposed in this paper rely on the well-known splitting of stochastic thermostat equations into a conservative and a fluctuation-dis...

Isolation of rotational isomer models of ethane-type molecules is described. We could experimentally prove that, if rotational isomers whose molecular shape was chiral, the molecule could be optically active, even though it did not carry an asymmetric carbon atom. As an extension, other types of stereochemically fundamental and optically active molecules were isolated and their absolute stereoc...

Anisotropic, elasto-viscoplastic behaviour in polycrystalline materials is modelled using a new, updated Lagrangian formulation based on a three-field form of the Hu-Washizu variational principle to create a stable finite element method in the context of nearly incompressible behaviour. The meso-scale is characterized by a representative volume element, which contains grains governed by single ...

Meso and large scale models tend nowadays to be non-hydrostatic. Time step restrictions due to fast waves are alleviated by considering semi-implicit schemes (Thomas et al, 2003) or by use of the anelastic approximation (Meso-NH model, Lafore et al, 1998, or Clark, 1977 among others); in both cases an elliptic equation has to be solved. This equation is typically ill conditioned, due to the ran...

Bacterial cell wall peptidoglycan (PGN) is a potent immunostimulator and immune adjuvant. The PGN of Gram-negative bacteria and some Gram-positive bacteria contain meso-diaminopimelic acid (meso-DAP), and we have recently shown that the intracellular protein Nod1 is a PGN receptor and recognizes DAP-containing peptides. In this study, we achieved the synthesis of DAP-containing PGN fragments, i...

BACKGROUND Children with extrahepatic portal hypertension typically present with cavernomatous transformation of the portal vein and a poorly defined intrahepatic portal vein system on conventional imaging. With the Meso-Rex Bypass becoming the gold-standard intervention for a cure, a precise assessment of the intrahepatic portal vein system provides helpful data for deciding whether a Meso-Rex...