A case of Churg-Strauss syndrome causing mesenteric intestinal ischaemia and small bowel necrosis is described in a 29-year-old man. Despite conservative management, the patient's condition deteriorated and he underwent five laparotomies. Small and medium-sized arteries within the mesentery and lymph nodes showed necrotizing vasculitis. Currently he is doing well on oral nutrition and medical m...

A young Turkish girl presented with all the clinicopathological features of a digestive form of alpha chain disease. A gamma heavy chain disease protein, however, was found in her serum and also in the cells invading the intestinal mucosa and mesenteric lymph nodes.

Immunoglobulin A (IgA)-secreting plasma cells beneath secretory epithelia probably represent the terminal differentiation stage of lymphocytes originating in Peyer's patches. Here, it is postulated (1), lymphocytes acquire a commitment to IgA synthesis. They proceed to the mesenteric lymph nodes (MN), 1 where they divide and differentiate into plasmablasts, then emigrate via the thoracic duct a...

Cell cultures prepared from the spleen and mesenteric lymph nodes of affected kittens were subjected to histochemical and ultrastructural studies. Macrophages in the cultures contained lipid in the cytoplasm and the ultrastructural studies revealed lysosomes containing lamellae similar in appearance to phospholipids.

A 72-year-old man with celiac disease was doing well on gluten-free diet. Five years later, he developed dyspepsia, fever and weight loss. CT scan and laparoscopic biopsies of small mesenteric lymph nodes clinched the diagnosis of Castleman's disease. He was started on chlorambucil; unfortunately he died few months after the diagnosis was made.

We report here invasin-dependent and invasin-independent mechanisms in which the enteropathogen Yersinia enterocolitica is able to disseminate from the lumen of the small intestine to the spleen. The invasin-dependent route is clearly discernible in mice devoid of intestinal Peyer's patches and mesenteric lymph nodes.

BACKGROUND Production of inflammatory cytokines by mesenteric adipose tissue (MAT) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Animal models of colitis have demonstrated inflammatory changes within MAT, but it is unclear if these changes occur in isolation or as part of a systemic adipose tissue response. It is also unknown what cell types are responsible for cy...

A 19-year-old girl referred to our clinic complaining of a painless lump on the left side of her tongue.  The patient had no history of dysphagia, lingual paresthesia or bleeding. Physical examination revealed the presence of multiple enlarged lymph nodes on the left side of her neck.  Histopathology of lingual mass and lymph nodes showed pleomorphic adenoma.  To our knowledge, this is the firs...

PURPOSE Bacterial translocation has been shown to occur in critically ill patients after extensive trauma, shock, sepsis, or thermal injury. The present study investigates mesenteric microcirculatory dysfunctions, the bacterial translocation phenomenon, and hemodynamic/metabolic disturbances in a rat model of intestinal obstruction and ischemia. METHODS Anesthetized (pentobarbital 50 mg/kg, i...

A highly conserved virulence plasmid encoding a type III secretion system is shared by the three Yersinia species most pathogenic for mammals. Although factors encoded on this plasmid enhance the ability of Yersinia to thrive in their mammalian hosts, the loss of this virulence plasmid does not eliminate growth or survival in host organs. Most notably, yields of viable plasmid-deficient Yersini...