BACKGROUND Management of patients with mental disorders is inadequate in the majority of low and middle income countries. The main treatment modality for patients with severe mental disorders in these countries is mainly pharmacological approach. Patients face many challenges in meeting medication needs. In this context, high percentages of individuals who have severe mental disorders are not t...

Adolescents who exhibit exaggerated blood pressure (BP) reactivity to physical and mental challenges are at increased risk of developing hypertension in adulthood. BP at rest and in response to challenges is higher in males than females, beginning in early adolescence. CYP17A1 is one of the well-established gene loci of adult hypertension. Here, we investigated whether this gene locus is associ...

Although 85% of HIV-positive adolescents reside in sub-Saharan Africa, little is known about the psychosocial and mental health factors affecting their daily well-being. Identifying these contextual variables is key to development of culturally appropriate and effective interventions for this understudied and high-risk population. The purpose of this study was to identify salient psychosocial a...

This paper challenges T. S. Gendler’s notion of aliefs, a novel kind of mental state which she introduces to explain a wide variety of belief-discordant behaviors. In particular, I argue that many of the cases which she uses to motivate such a mental state can be fully explained by accounts that make use only of commonplace attitudes such as beliefs and

This paper enumerates and briefly discusses WHO's recent contributions to global mental health and the current challenges and opportunities in this area. It briefly discusses response to diversity across countries and communities, the need for innovations and global exchange of information, evidence and knowledge and raises issues like psychological interventions and human rights related to men...

It is now time to begin the study of personal genome services based on the interdisciplinary theories and technologies of genomics and artificial intelligence (AI). Although recently much attention has been given to personal genome services for realizing personal medicine, little systematic research has been done on their communication and computational aspects for intelligent wellness service ...

RoboCup was started in 1997 by a group of Artificial Intelligence and Robotics researchers with the following grand challenge, to be achieved by 2050 [9]: “to build a team of robot soccer players, which can beat a human World Cup champion team.” Since then, RoboCup Federation1 established itself as a structured organization and as one of the major events in the research field of Artificial Inte...

Servitization is a grand challenge for all manufacturing companies to extend their business. As main result this paper presents an approach and corresponding research questions on how to integrate servitization in manufacturing businesses by making use of an innovation ecosystem. Companies might benefit from this approach, as it indicates how relevant characteristics to evolve in order to take ...

In March 2010, the Dagstuhl Seminar 10102 explored the grand challenges confronting research and practice in the domain of discrete event logistics systems. This Executive Summary describes the process of the seminar and discusses the key conclusions regarding grand challenges for research and practice. Abstracts of the presentations given during the seminar are put together in the online proce...

BACKGROUND Mental illness may cause a variety of psychosocial problems such as decreased quality of life of the patient's family members as well as increased social distance for the patient and the family caring for the patient. Psychosocial challenges are enhanced by the stigma attached to mental illness, which is a problem affecting not only the patient but also the family as a whole. Coping ...