Down syndrome (DS) is the most common chromosomal anomaly occurring in live births (Capone et al, 2004; Menkes & Falk, 2005) and it has been described as a syndrome-complex of genetic origin with protean neurobiological consequences, and several characteristic neurodevelopmental and neuropsychological manifestations. Down syndrome is also considered to be the most common single cause of mild, m...

A study has been carried out on the analysis of physical and chemical quality PDAM water in Teluk Ambon Baguala sub-district. The purpose this was to analyze from Regional Drinking Water Company (PDAM) Halong, Lateri, Passo villages, including smell, taste, color, temperature, a total dissolved solids (TDS), pH hardness. method used is observation field at time sampling, then measurement labora...

Macklem, P T (1975). The use of a helium-oxygen mixture during maximum expiratory flow to demonstrate obstruction in small airways in smokers. Journal of Clinical Investigation, 55, 1090-1099. Fry, D L, and Hyatt, R E (1960). Pulmonary mechanics. American Journal of Medicine, 29, 672-689. Hogg, J C, Macklem, P T, and Thurlbeck, W M (1968). Site and nature of airway obstruction in chronic obstru...

The Wilson disease protein (WND) is a transport ATPase involved in copper delivery to the secretory pathway. Mutations in WND and its homolog, the Menkes protein, lead to genetic disorders of copper metabolism. The WND and Menkes proteins are distinguished from other P-type ATPases by the presence of six soluble N-terminal metal-binding domains containing a conserved CXXC metal-binding motif. T...

The redox properties of Copper (Cu) make it both an ideal cofactor for many enzymes, and, in its free form, a highly toxic molecule capable of stimulating production of reactive oxygen species or binding to protein thiol groups. Therefore, living organisms have evolved homeostatic systems to “handle” Cu avoiding dangerous and wasteful aspecific interactions. These systems comprise uptake, carri...