World Health Organization (WHO)'s declaration on July 23, 2022 regarding Mpox (previously Monkey pox) outbreak appeared as Public Emergency of International Concern (PHEIC). Although, WHO, in May 2023 declared an end to the global health emergency for Mpox, but still, it is still prevalent and public awareness should continue.1 This viral Zoonotic contagious disease was first discovered 1958 wh...

INTRODUCTION The aim of this study was to derive a novel prognostic score for mortality in paediatric meningococcal sepsis (MS) based on readily available laboratory markers. METHODS A multicentre retrospective cohort study for the consortium set and a single centre retrospective study for replication set. The consortium set were 1,073 children (age 1 week to 17.9 years) referred over a 15-ye...

PURPOSE Prompt recognition and aggressive early treatment are the only effective measures against invasive meningococcal disease (IMD). Anti-inflammatory adjunctive treatment remains controversial and difficult to assess in patients with IMD. The purpose of this study was to evaluate the effect of dexamethasone (DXM) as adjunctive treatment in different clinical forms of IMD, and attempt to ans...

79 the same as that for previous editions. Everything considered, this volume maintains the high standard of excellence which the earlier editions established. Medical literature abounds with voluminous clinical experiences, the significance of which is too frequently obscured by irrelevant detail and unnecessary statistics. Thus, intelligent evaluation is inhibited and important observations a...

Septic arthritis is an Orthopaedic emergency, threatening the joint within hours of onset. Up to 10% of cases of meningococcaemia have an associated septic arthritis. The aetiology of acute meningococcaemia in a variety of clinical syndromes is well documented in the literature. The pathogen Neisseria meningitidis can cause both primary and secondary manifestations of disseminated infection. Br...

Purpura fulminans is a rare and severe complication of meningococcal septicaemia. It presents as a petechial rash spreading rapidly in extent and depth, evolving into full-thickness skin necrosis. The condition is extremely uncommon in the adult population. We report the case of a 28-yr-old man with extensive meningococcal-related skin necrosis. The initial diagnosis was made and first treatmen...

BACKGROUND The use of the lumbar puncture in the diagnosis of central nervous system infection in acutely ill children is controversial. Recommendations have been published but it is unclear whether they are being followed. METHODS The medical case notes of 415 acute medical admissions in a children's hospital were examined to identify children with suspected central nervous system infection ...

Bacterial meningitis is a relatively common infection of the cerebrospinal fluid (CSF) and leptomeninges. The clinical picture evolves rapidly and, if treatment is delayed, can result in a variety of long-term sequelae, including death. Acute kidney injury in the setting of bacterial meningitis usually results from hypotension and volume depletion and resolves with appropriate treatment. Mening...

Accessible online at: www.karger.com/res The paper by Salama et al. [1, this issue of Respiration] correlating elevated serum Fas levels with cor pulmonale in schistosomiasis (caused by a subgroup of trematodes – flukes) may have broad implications for respiratory physicians. The Fas receptor and Fas ligand (CD95) system, being respectively related to the TNF-receptor (R) and the TNF families, ...

Neisseria meningitidis is a human-specific pathogen with capacity to cause septic shock and meningitis. It has been hypothesized that invasion of the central nervous system (CNS) is a complication of a bacteremic condition. In this study, we aimed to characterize the invasion route of N. meningitidis to the CNS. Using an intranasally challenged mouse disease model, we found that twenty percent ...