نتایج جستجو برای: memory b cells

تعداد نتایج: 2292637  

Journal: :Neuroscience letters 2009
Masaaki Niino Makoto Hirotani Yusei Miyazaki Hidenao Sasaki

Memory and naïve B cells are considered to play distinct roles in immune regulation. However, the roles of memory and naïve B-cell subsets in multiple sclerosis (MS) have not yet been elucidated. In this study, we examined whether memory and naïve B-cell subsets differ between patients with MS and healthy subjects and whether interferon beta (IFNbeta)-1b can affect these subsets in patients wit...

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Journal: :Journal of immunology 2009
Kim L Good Danielle T Avery Stuart G Tangye

Enhanced secondary Ab responses are a vital component of adaptive immunity, yet little is understood about the intrinsic and extrinsic regulators of naive and memory B cells that result in differences in their responses to Ag. Microarray analysis, together with surface and intracellular phenotyping, revealed that memory B cells have increased expression of members of the TNF receptor, SLAM (sig...

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Journal: :Journal of immunological methods 2010
Geraldine Blanchard-Rohner Grazia Galli Elizabeth A Clutterbuck Andrew J Pollard

In the present study, the limiting dilution assay (LDA) and the ELISpot are compared in their ability to detect serogroup C meningococcal (MenC)-specific memory B-cells in peripheral blood of 12month old children, after 3-dose priming with serogroup C meningococcal conjugate vaccine (MenCV) in infancy. At 12 months of age, MenC-memory B-cells were detected by ELISpot in 61% of children and in 5...

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Journal: :Journal of immunology 2001
D J Driver L J McHeyzer-Williams M Cool D B Stetson M G McHeyzer-Williams

We have recently demonstrated that a novel somatically mutated B220(-) memory B cell subset rapidly dominates the secondary immune response to (4-hydroxy-3-nitrophenyl) acetyl (NP). Upon adoptive transfer with Ag, B220(+)NP(+) memory B cells produce large numbers of B220(-)NP(+) B cells that can rapidly differentiate into plasma cells. Therefore, it is not clear whether the novel B220(-) memory...

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2016
Kara S. Cox Aimin Tang Zhifeng Chen Melanie S. Horton Hao Yan Xin-Min Wang Sheri A. Dubey Daniel J. DiStefano Andrew Ettenger Rachel H. Fong Benjamin J. Doranz Danilo R. Casimiro Kalpit A. Vora

Monitoring antigen-specific memory B cells and the antibodies they encode is important for understanding the specificity, breadth and duration of immune response to an infection or vaccination. The antibodies isolated could further help design vaccine antigens for raising relevant protective immune responses. However, developing assays to measure and isolate antigen-specific memory B cells is t...

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Journal: :The Journal of Immunology 2009

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Journal: :Frontiers in Immunology 2012

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Journal: :Nature 2019

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Journal: :Proceedings of the National Academy of Sciences 2007

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Journal: :Journal of Experimental Medicine 2006

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