Objective— Use of equine autologous keratinocyte on collagen membrane grafts (KCMG) for treatment of wounds in the distal aspect of the horse limb. Design— Experimental study Animals— Four horses. Procedure—Keratinocytes have been separated by enzyme digestion from lib skin sample and proliferated in vitro. Full thickness excision wounds (6.25 cm2) were created on the mid-lateral of both met...

Milk thistle (Silybum marianum) is a native plant of Mediterranean Sea areas. Silymarin, an extract from its seeds, is used in various liver diseases for its hepatoprotective effects. It contains silymarin flavonoids (SF) such as silybin, silydianin and silychristin. Cyclosporin A (CsA) is widely used as an immunosuppressant in organ transplantations. Its other applications in many autoimmune d...

One of the most important Fuel cells (FCs) is Proton Exchange Membrane Fuel Cells (PEMFCs). The outputvoltage of this FC depends on current loads. This paper tries to introduce, implement and control the voltage ofPEMFC, during load variations. The output voltage of fuel cell should be constant during load variation. Toachieve this goal, a controller should be designed. Here, the Lead-Lag contr...

Background: Phenolic compounds, which are produced routinely by industrial and urban activities, possess dangers to live organisms and environment. Laccases are oxidoreductase enzymes with the ability of remediating a wide variety of phenolic compounds to more benign molecules. The purpose of the present research is surface display of a laccase enzyme with adhesin involved in diffuse adhesion (...

Inhibition of matrix-metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs) has been shown in vivo to decrease metastasis and tumor-associated angiogenesis. Our laboratory is interested in understanding the role of these proteins at the pericellular microenvironment of tumor and endothelial cells. Secretion of MMPs by tumor cells enables the migration, invasion and metasta...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

Mechanosensing is a key feature through which organisms can receive inputs from the environment and convert them into specific functional behavioral outputs. Mechanosensation occurs in many cells tissues, regulating plethora of molecular processes based on distribution forces stresses both at cell membrane intracellular organelles levels, complex interactions between cells’ microstructures, cyt...

The uptake and transport of 9-nitrocamptothecin (9-NC), a potent anticancer agent, across Caco-2 cell monolayers was studied as a free and PLGA nanoparticle loaded drug. Different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. The transport of nanoparticles across the Caco-2 cell monolayer as a func...

The uptake and transport of 9-nitrocamptothecin (9-NC), a potent anticancer agent, across Caco-2 cell monolayers was studied as a free and PLGA nanoparticle loaded drug. Different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. The transport of nanoparticles across the Caco-2 cell monolayer as a func...