mediated mrna

با توجه به مشکلات متعدد و عوامل مختلف در غیر فعالسازی سلول های دندریتیک و پاسخ های ایمنی، در ریزمحیط تومور و ایمونوتراپی ها، نیاز به روشی مطمئن، موثر و کاربردی در روندهای ایمونوتراپی می باشد. بدین منظور در این تحقیق تلاش گردید میزان بیان cd40 و icosl را بر روی سلول های دندریتیک افزایش داده شوند که این کار با استفاده از انتقال mrna این مولکلول ها انجام گرفت و در عین حال سلول ها با mrna تام تومور...

increased urinary neopterin: creatinine ratio as a marker of activation of cell-mediated immunity and oxidative stress in the iranian patients with multiple sclerosis

Journal: :iranian journal of allergy, asthma and immunology 0

h. khorami tr. neyestani mehri. kadkhodaee j. lotfi

neopterin, apyrazinopyrimidine compound, is produced by macrophages after induction by interferon gamma (ifn-y) and serves as a marker of cellular immune system activation followed by oxidative stress. the aim of this study was to determine urinary neopterin to creatinine ratio (uncr) as a surrogate marker of cell-mediated immune activation in multiple sclerosis (ms). three weekly early morning...

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From disease modelling to personalised therapy in patients with CEP290 mutations

2017

Elisa Molinari Shalabh Srivastava John A Sayer Simon A Ramsbottom

Mutations that give rise to premature termination codons are a common cause of inherited genetic diseases. When transcripts containing these changes are generated, they are usually rapidly removed by the cell through the process of nonsense-mediated decay. Here we discuss observed changes in transcripts of the centrosomal protein CEP290 resulting not from degradation, but from changes in exon u...

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Disrupted auto-regulation of the spliceosomal gene SNRPB causes cerebro–costo–mandibular syndrome

2014

Danielle C. Lynch Timothée Revil Jeremy Schwartzentruber Elizabeth J. Bhoj A. Micheil Innes Ryan E. Lamont Edmond G. Lemire Bernard N. Chodirker Juliet P. Taylor Elaine H. Zackai D. Ross McLeod Edwin P. Kirk Julie Hoover-Fong Leah Fleming Ravi Savarirayan Kym Boycott Alex MacKenzie Michael Brudno Dennis Bulman David Dyment Jacek Majewski Loydie A. Jerome-Majewska Jillian S. Parboosingh Francois P. Bernier

Elucidating the function of highly conserved regulatory sequences is a significant challenge in genomics today. Certain intragenic highly conserved elements have been associated with regulating levels of core components of the spliceosome and alternative splicing of downstream genes. Here we identify mutations in one such element, a regulatory alternative exon of SNRPB as the cause of cerebro-c...

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