OBJECTIVE Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in carotid intima media thickness and total plaque area in a general population. APPROACH AND RESULTS Subjects were 1532 women and 1442 men who participated in a longitudinal population-based study with ul...

[Purpose] The aim of this study was to examine the relationships between the amount and distribution of body fat and the carotid intima-media thickness to explore whether coronary artery disease risk may be mediated through effects on the amount of fat mass in older adults. [Subjects and Methods] A total of 200 elderly females was participated. The percentage of body fat mass was measured by th...

OBJECTIVE To evaluate the association of the V249I and T280M variants of CX3CR1 fractalkine gene with carotid intima-media thickness in Mexican subjects with and without type 2 diabetes. METHODS We analyzed the V249I and T280M variants of the CX3CR1 receptor by TaqMan assays in 111 subjects with type 2 diabetes and 109 healthy controls. Hemoglobin A1c, glucose, and lipid profile were determin...

OBJECTIVE Aberrations in apolipoprotein (apo) metabolism and increased systemic inflammation associate with the metabolic syndrome (MetS) and may contribute to its atherogenicity. We examined whether the association between carotid atherosclerosis and MetS in a population of young adults is mediated by apoB and apoA-I and/or by inflammatory markers C-reactive protein and type II secretory phosp...

Background : Carotid intima-media thickness (CIMT) has been proposed as a surrogate marker to identify diabetic patients at higher risk for CAD. Oxidative stress has been postulated to be involved in the development of atherosclerosis. Objective: The present study was to evaluate the effect of taurine on serum lipids, lipid peroxidation and RBC antioxidant status and vessel changes in type 2dia...

Bone mineral density (BMD) has been suggested to be associated with atherosclerosis. In the present study, we evaluated the association between lumbar BMD and the segments of carotid intima-media thickness (CIMT), a surrogate marker of subclinical atherosclerosis, in Korean adults, with consideration of sex and menopause status. Among 1,679 Korean adults who enrolled in a Healthy Twin Study, 72...

Keywords: Cardiovascular risk factors Carotid intima-media thickness Kidney transplant recipients South Africa. Background: Cardiovascular diseases (CVD) are more common in kidney transplant recipients (KTRs) than in the general population. Carotid intima-media thickness (cIMT) is a marker of atherosclerosis in the general and transplant populations. We determined the prevalence and predictors ...

BACKGROUND AND PURPOSE Central nervous system serotonergic neurotransmission appears to play a role in mood disorders, eating habits, and sleep, and also modulates blood pressure and metabolism. This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis. METHODS Subjects were 244 adults 30 to 55 years of age and free of clinic...

BACKGROUND Stroke is one of the major causes of death worldwide. The importance of increased intima-media thickness in cardiovascular risk stratification has been recurrently studied. The relationship between them, however, is still controversial. OBJECTIVES To determine whether increased common carotid artery (CCA) intima-media thickness can be used as an independent high-risk marker for the...

BACKGROUND AND PURPOSE The recent finding that genetic variation in the leukotriene biosynthesis pathway may confer an increased risk of ischemic stroke and atherosclerosis has implicated the leukotriene family as potential mediators of cardiovascular disease. Using a 2-stage replication design, we have examined whether polymorphisms in 8 genes related to this pathway are associated with early ...