OBJECTIVES The factors determining individuals' self-reported behavioural responses to direct to consumer advertising of prescription drugs were explored with an emphasis on 'at-risk' individuals' responses. DESIGN Nationally representative cross-sectional survey. SETTING Community living adults in New Zealand. PARTICIPANTS 2057 adults (51% women). PRIMARY OUTCOME MEASURES Self-reported...

AQM (Active Queue Management) mechanisms support an end-to-end congestion control mechanism of TCP (Transmission Control Protocol). Researchers have claimed several advantages of AQM mechanisms over a conventional Drop-Tail gateway such as the small average queue length (i.e., the number of packets in the buffer). Several AQM mechanisms have been recently proposed and studied by many researcher...

In a previous publication (2) a double displacement mechanism for the catalytic activity of rhodanese (thiosulfate cyanide sulfurtransferase) was proposed on the basis of polarographic evidence. In addition it was concluded from the polarographic data that crystahine beef liver rhodanese is an enzyme-substrate intermediate containing two activated substrate sulfur atoms per molecule. This commu...

Microtubules are key components of the cytoskeleton of eukaryotic cells and play important roles in many aspects of biological functions. Development of microtubule inhibitors, which interfere with microtubule assembly and disassembly specific in the M phase, is useful for the investigation of the biological function of microtubules and microtubule-associated proteins (MAPs) as well as for canc...

Phagocytic leukocytes have on their plasma membranes receptors for the Fc portion of immunoglobulin G (IgG) (1-9) and for a cleavage product of the third component of complement (C3) (3-5, 8, 10-15). Particles coated with IgG or C3 attach to the corresponding receptors on the plasma membranes of phagocytic cells. We have been studying the roles of these ligands (IgG and C3) and of their recepto...

In the chronic active stage of hemorrhagic Bright's disease there are often comparatively long intervals when the amount of functioning kidney tissue decreases very slowly and when there is no marked variation in glomerular permeability. With the patient on a standard regime the urea clearance remains constant, proteinuria fairly so, and blood samples taken under basal conditions with precautio...

The intradermal injection of filtered bacterial toxin derived from certain Gram-negative microorganisms produces, in rabbits, little evidence of primary damage to the skin other than varying degrees of local inflammatory reaction. The skin may show mild erythema, usually with slight thickening of the injected area. Mter an interval of 12 to 18 hours, an intravenous injection of the same materia...

Fibrillar type flight muscle powers the flight machinery of the more phylogenetically advanced groups of flying insects. A comparison of responses from single fibers in insects from various orders having fibrillar muscle reveals fundamental differences. In single fibers of flies and wasps the response to a single threshold stimulus is an all-or-none, uniformly rising, in most cases overshooting...

THE decarboxylase-inhibiting, sedative, and antihypertensive properties of amethyl-3,4-dihydroxy-DI,-phenylalanine (DL-amethyl-dopa) in man were first reported from this department in 1960.1 It was shown subsequently that these three properties of the compound reside solely in the L isomer (methyldopa, Aldomet) .2, 3 Numerous favorable reports on the use of methyldopa in the treatment of hypert...

reactants, reagents, and catalysts. A wide variety of performances of transition-metal catalysts are considerably dependent on the electronic states belonging to d-orbital electrons having dif ferent oxidative or spin states designed by coordinated ligands. To explore high-performance catalysts, analytical investigation based on electronic states is necessary, and theoretical calculations are i...