The periodontium, which is responsible for the retention of teeth in the maxilla and mandible, consists of four tissue types. Cementum and alveolar bone are the hard tissues to which the fibrous periodontal ligament anchors the tooth into the skeleton, and the gingiva is the covering tissue of the periodontium (Fig. 42.1). The gingiva is a unique body tissue in that it allows the penetration of...

The periodontal ligament (PDL) contains oxytalan fibers as well as collagen fibers, which helps it to withstand the mechanical stress to which it is constantly exposed. The oxytalan fibers are produced by PDL fibroblasts. However, the arrangement of PDL fibroblasts and the orientation of oxytalan fibers relative to the fibroblast cell axis have not been investigated under the condition of mecha...

Cell-based tissue repair of the tooth and - tooth-supporting - periodontal ligament (PDL) is a new attractive approach that complements traditional restorative or surgical techniques for replacement of injured or pathologically damaged tissues. In such therapeutic approaches, stem cells and/or progenitor cells are manipulated in vitro and administered to patients as living and dynamic biologica...

Considered to be the "holy grail" of dentistry, regeneration of the periodontal ligament in humans remains a major clinical problem. Removal of bacterial biofilms is commonly achieved using EDTA gels or lasers. One side effect of these treatment regimens is the etching of nanotopographies on the surface of the tooth. However, the response of periodontal ligament fibroblasts to such features has...

Background The present study aims to comparatively evaluate the isolation and quantification of stem cells derived from dental pulp and periodontal ligament of a permanent tooth and to assess their viability and proliferation on a platelet-rich fibrin (PRF) scaffold. Materials and Methods A total of 15 systemically healthy individuals between the age group of 15-25 years requiring third molar...

INTRODUCTION The purpose of this study was to quantify the effect of three different rotary root canal preparation systems on substance P and calcitonin gene-related peptide expression in healthy human periodontal ligament. METHODS Fifty periodontal ligament samples were obtained from healthy premolars in which extraction was indicated for orthodontic reasons. Before extraction, 40 of these p...

introduction: the purpose of this study was to evaluate external root surface temperature rise during post space preparation using la axxess bur, beefill pack system, and peeso reamer drill. materials & methods: the distal canals of forty-five extracted human permanent mandibular first molars were instrumented in crown-apical manner and obturated with lateral condensation technique. teeth were ...

Regeneration is defined as a reproduction or reconstruction of a lost or injured part in a way that both form and function of lost tissues are completely restored (Wikesjö and Selvig, 1999; Caton and Greenstein, 1993; Machtei, 1997; World Workshop in Periodontology, 1996). Regenerative periodontal therapy aims to predictably restore the tooth’s supporting apparatus which has been lost following...