BACKGROUND Biochemical evidence has linked the coordinate control of fatty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). The ratio of 16:1n-7 to 16:0 [SCD1₁₆] in plasma triacylglycerol FA has been used as an index to reflect liver SCD1₁₆ activity and has been proposed as a biomarker of FA synthesis, although this use has not been validated by comparison with isotopi...

ExEcutivE Summary Cardiotoxicity screening is in a state of flux. It is evident that screening for hERG block in immortalized cell lines and QT interval prolongation in animals as recommended by the ICH S7B guidelines is limited in predicting a drug's risk of causing the potentially fatal arrhythmia, Torsades de Pointes (TdP). The " Thorough QT study, " required by the FDA/ICH E14 safety guidel...

Experience with existing multilateral environmental agreements (MEAs) shows that trade measures agreed to within the MEAs themselves may not necessarily lead to a dispute between parties. On the contrary, there is a great chance that disputes may arise from national measures undertaken to fulfil those obligations under the MEAs. This possibility of conflict with their WTO obligations may well a...

Abstrak. Penelitian ini bertujuan untuk melihat perbedaan kemampuan pemahaman konsep matematis serta self confidence siswa yang mendapatkan pembelajaran Model Eliciting Activities dengan model secara langsung pada materi Bangun datar segitiga di kelas VII. menggunakan desain Quasi Eksperimental rancangan the nonequivalent posstest-only control group design. Populasi dalam penelitian adalah semu...

Manufacturing organizations are implementing sustainability practices to be-come more sustainable. Understanding the manufacturing in-volves indicators which provides a quantitative or qualitative way of meas-ure success in suitability organization. Hence present paper analyses studies conducted field sustainable and identifies socio-economic indica-tors frequently used by researches. From revi...