Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) are frequently co-morbid, and dysfunctional frontal-striatal circuits have been implicated in both disorders. Neurobiological distinctions between OCD and MDD are insufficiently clear, and comparative neuroimaging studies are extremely scarce. OCD and MDD may be characterized by cognitive rigidity at the phenotype level, an...

Women are more vulnerable to major depressive disorder (MDD) than men. However, molecular biomarkers of sex differences are limited. Here we combined gas chromatography-mass spectrometry (GC-MS)- and nuclear magnetic resonance (NMR)-based metabonomics to investigate sex differences of urinary metabolite markers in MDD, and further explore their potential of diagnosing MDD. Consequently, the met...

BACKGROUND Despite the increased risk for suicidal ideation (SI) in children of mothers with a history of major depressive disorder (MDD), little is known about specific risk factors for SI in these children. The present study is the first to our knowledge to examine the potential role of biases in the identification of facial expressions of emotion. METHODS Participants were 202 children (ag...

The aim of our study is to examine the levels of routine biochemical markers in patients with major depressive disorder (MDD), and combine multiple biochemical parameters to assess the discriminative power for patients with MDD. We used the Hamilton Depression (HAMD) score to evaluate the severity of depressive symptoms in 228 patients with MDD. The phase of depression severity was between mode...

Capgemini sd&m setzt seit über 15 Jahren modellgetriebene Generatoren in seinen Projekten ein. Bisher wurden immer wieder neue Infrastrukturen aufgesetzt, Modellierungssprachen entwickelt und Generatoren gebaut. Jetzt entwickeln wir einen einheitlichen Modellierungsund Generierungs-Ansatz. Dabei setzen wir auf die MDD-Werkzeuge im Umfeld der Eclipse-Plattform. Wir integrieren Werkzeuge wie Ecli...

Model-Driven Development (MDD) is a software development paradigm that promotes the use of models at different levels of abstraction and perform transformations between them to derive one or more concrete application implementations. In this paper we analyze the current status of MDD regarding its applicability for the development of Real-Time Embedded Software. We discuss different modeling fr...

This study examined whether adolescents with major depressive disorder (MDD) display the abnormal electroencephalographic (EEG) alpha asymmetries found in depressed adults. Resting EEG was recorded in 25 right-handed female outpatients (19 with MDD, 11 of whom also had a current anxiety disorder; 6 with anxiety disorders only) and 10 non-ill controls. In contrast to the non-ill controls, adoles...

Sixty-one adolescents hospitalized on an inpatient psychiatric unit were evaluated to determine whether they met criteria for panic and affective disorders according to Research Diagnostic Criteria. Ten (16%) and 15 (24%) met criteria for definite or possible panic disorder. Fifteen (24.5%) had major depressive disorder (MDD) endogenous subtype, 10 (16%) had MDD nonendogenous subtype, 8 (13%) h...

Stressful life events (SLEs) and neuroticism are risk factors for Background: major depressive disorder (MDD). However, SLEs and neuroticism are heritable and genetic risk for SLEs is correlated with risk for MDD. We sought to investigate the genetic and environmental contributions to SLEs in a family-based sample, and quantify genetic overlap with MDD and neuroticism. A subset of Generation Sc...

OBJECTIVE Patients with major depressive disorder (MDD) clinically exhibit a deficit in positive emotional processing and are often distracted by especially negative emotional stimuli. Such emotional-cognitive interference in turn hampers the cognitive abilities of patients in their ongoing task. While the psychological correlates of such emotional conflict have been well identified in healthy ...