objectives: the antioxidant capacity impairs in kidney and urinary bladder of animals with stone disease. herbal medicine can improve the antioxidant condition of renal tissue. cynodon dactylon (c. dactylon) is a medicinal plant with antioxidative and diuretic properties and different preparations of this plant have shown promising effects in stone disease. assessment of the whole plant decocti...

methylsulfonylmethane (msm) is a sulfur-containing compound commonly found in diet and known to reduce oxidative stress. this trial was conducted to determine whether single dose supplementation with msm attenuates post-exercise oxidative stress in healthy untrained young men. sixteen untrained men volunteered for this study. participants were randomized in a double-blind placebo-controlled fas...

introduction: this study was designed to evaluate the effects of treatment with flaxseed oil (fso) on renal ischemia-reperfusion (rir) injuries in rats. materials and methods: in this study, 32 wistar rats were randomly studied in four groups: co+ns (control group with normal saline administration), sh+ns (sham group with normal saline administration), rir+ns and rir+fso. fso (0.2 ml) was admin...

No generally accepted understanding on the characteristics of MDA transformation mechanisms exists. Various approaches to support such transformations have been proposed. In this paper, we discuss general requirements for MDA transformation mechanisms. We claim that, above all else, transformation mechanisms should be open, i.e. clear, transparent and user-guided. We propose a new concept, a tr...

OBJECTIVE To evaluate the effect of repeated mass drug administration (MDA) of azithromycin in the Gambia on the nasopharyngeal carriage of Streptococcus pneumoniae and on the emergence of antibiotic-resistant strains. METHODS This study involved villages that participated in a cluster randomized trial comparing the effect of one versus three azithromycin MDA rounds on the prevalence of trach...

The MDA-468 human breast cancer cell line has an amplified epidermal growth factor (EGF) receptor gene (20 x) and correspondingly overexpresses the EGF receptor. Since this cell line is growth inhibited by supra-physiological levels of EGF in tissue culture, it has been possible to select variant cells which have lost the chromosome bearing the amplified EGF receptor domain and which are capabl...

BACKGROUND The lymphatic filarial parasite Brugia timori occurs only in eastern Indonesia where it causes high morbidity. The absence of an animal reservoir, the inefficient transmission by Anopheles mosquitoes and the high sensitivity to DEC/albendazole treatment make this species a prime candidate for elimination by mass drug administration (MDA). METHODOLOGY/PRINCIPAL FINDINGS We evaluated...

The transcriptional co-regulator Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain-2 (CITED2) may promote breast tumor growth; however, the mechanisms by which its effects are mediated remain to be fully elucidated. Tumor-associated macrophages serve an important function in tumor development and progression and are recruited by chemotactic factors produced by cells ...