Homeobox containing transcription factors are frequently deregulated in human hematologic malignant diseases either indirectly through an abnormality of an upstream factor, or directly through rearrangement of the gene itself. Study of T-cell acute lymphoblastic leukemia identified the related non-clustered homeobox transcription factors, TLX1 and TLX3, as frequently ectopically expressed as a ...

Leukemia is a cancer of blood-producing cells, including the bone marrow. Abnormal white blood cells travel through vessels and multiply rapidly. Healthy in body become minority, imbalance increases chances infection body. or most common children ages 2 - 14. Most leukemia treated. Acute lymphocytic (ALL) type It progresses rapidly when immature are formed instead mature ones. Treatments for ac...

Mature cystic teratoma (MCT) is the most common type of ovarian germ cell tumor occurring in females of reproductive age. It is typically benign, but rare malignant transformations have been reported in 1-2% of the cases. Among a wide variety of malignancies arising in MCTs, high grade lymphomas are the least common. We present a case of a 45- years -old female with a unilateral adnexal ma...

correct diagnosis and classification of lymphoid neoplasms depends on the integration of morphologic, immunophenotypic and molecular genetic features. the mature small b cell lymphomas despite their overlapping histomorphologies, have different clinical behavior and treatment. in this review, differential diagnosis of this category of tumors and a practical approach based on biomarkers evaluati...

Abstract Siglec-15 (Sig15) has been implicated as an immune checkpoint expressed in solid tumor-infiltrating macrophages and is being targeted clinical trials with monoclonal antibodies to normalize the tumor microenvironment stimulate anti-tumor immunity. However, role of Sig15 hematological malignancies remains undefined. mRNA protein expression levels were determined from publicly available ...