نتایج جستجو برای: matrix metalloproteinase 9
تعداد نتایج: 824768 فیلتر نتایج به سال:
Objective: To investigate the expression of matrix metalloproteinase-2 (MMP-2), metalloproteinase-9 (MMP-9), and transforming growth factor beta 1 (TGF 1) in kidney tissue rats with pyelonephritis their relationship by establishing a rat model acute pyelonephritis. Methods: 80 male Wistar were randomly divided into control group an experimental group, 40 each. The injected saline those 10 ?g/mL...
Alzheimer's disease (AD) is the most prevalent type of dementia. Pathological changes in the AD brain include amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), as well as neuronal death and synaptic loss. Matrix metalloproteinases (MMPs) play an important role as inflammatory components in the pathogenesis of AD. MMP-2 might be assumed to have a protective role in AD and is the major M...
Aberrant activation of matrix metalloproteinases (MMPs) is a common feature of pathological cascades observed in diverse disorders, such as cancer, fibrosis, immune dysregulation, and neurodegenerative diseases. MMP-9, in particular, is highly dynamically regulated in several pathological processes. Development of MMP inhibitors has therefore been an attractive strategy for therapeutic interven...
To observe the inhibitory effect of plumbagin on invasion and migration glioma cells U-118 to explore possible mechanism its action. were cultured in medium with different concentrations counted morphological changes observed under microscope after 24 h incubation cell proliferation was detected by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide, scratching assay Transwell method...
To determine the effect of giving a combination Annona squamosa leaf extract and cisplatin on matrix metalloproteinase-9 expression inhibition cell migration in HeLa cells. The sample this study was divided into 6 groups: group 1 as control group, 2 single (Cis) 3-5 different combinations with ASL 12.5, 25 mg/mL, 50 mg/mL respectively, 75 group. This research included cytotoxicity test MTT assa...
Background & Aims: This study was performed to investigate possible relationships between the manifestation of stromal cells (fibroblasts and/or myofibroblasts) by focusing on expression of their matrix metalloproteinase 9 (MMP9) and possible angiogenesis based on CD31 and CD34 antigen expression during the various steps of hyperplastic changes to precancerousstate and invasive breast cancer. M...
Matrix metalloproteinases (MMPs) degrade all of the extracellular matrix components of the intersititium and may play a role in abnormal alveolar permeability, which is a feature of idiopathic pulmonary fibrosis (IPF). The aims of the present study were to evaluate MMP protein levels in patients with IPF and determine any relationship to treatment and markers of permeability. In total, 20 patie...
Background & Objective: Matrix metalloproteinases-9 (MMP-9) is one of the most important enzymes to breakdown extracellular matrix which plays a major role in tumor invasion and metastasis. This study aimed to determine tumor MMP-9 expression in non-small-cell lung carcinoma (NSCLC) and whethe...
Matrix metalloproteinases (MMP-) are involved in leukocyte invasion into the central nervous system (CNS) during inflammation. In a retrospective cohort study of 18 neuro-BD patients, CSF samples were studied for MMP-9, TIMP-1 and cell characteristics in neuro-BD patients compared to 12 Headache attributed to BD (HaBD) patients, 15 multiple sclerosis (MS) and 20 Non-inflammatory Neurological Di...
Cashew nut shell liquid (CNSL) has been used in traditional medicine for the treatment of a wide variety of pathophysiological conditions. To further define the mechanism of CNSL action, we investigated the effect of cashew nut shell extract (CNSE) on two matrix metalloproteinases, MMP-2/gelatinase A and MMP-9/gelatinase B, which are known to have critical roles in several disease states. We ob...
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