We identified a novel mechanism of hereditary thrombosis associated with antithrombin resistance, with a substitution of arginine for leucine at position 596 (p.Arg596Leu) in the gene encoding prothrombin (called prothrombin Yukuhashi). The mutant prothrombin had moderately lower activity than wild-type prothrombin in clotting assays, but the formation of thrombin-antithrombin complex was subst...

It is widely acknowledged that the approach taken in the development of a classification of mental disorders is guided by various values and assumptions. The author, who played a central role in the development of DSM-III (American Psychiatric Association [1980] Diagnostic and statistical manual of mental disorders, 3rd ed. Washington, DC:Author) and DSM-III-R (American Psychiatric Association ...

The presence of an antithrombin in normal plasma and serum has been known for many years. In 1892 Schmidt postulated its existence when he observed the rapid disappearance of thrombin from blood after coagulation. Tests have been devised enabling the titre of antithrombin to be determined. Most of these tests depend on the inactivation of serial dilutions of thrombin of known concentration by t...

Insect lipoprotein termed as apolipophorin III (apoLp-III), has a unique five-helix bundle protein structure. The protein is used by insects to supply high supply of energy to their flight muscles (wings) during unstopped long-distance migration. However, it is not clear why compared to most prominent four-helix bundle protein structure found in nature, apoLp-III has five helix bundles. This re...

To analyze inherited antithrombin deficiency as a risk factor for venous thromboembolism in various conditions with regard to the presence or absence of additional genetic or acquired risk factors, we compared 48 antithrombin-deficient individuals with 44 nondeficient individuals of 14 selected families with inherited antithrombin deficiency. The incidence of venous thromboembolism for antithro...

Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double-stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two related functions, highlighting models of Dros...

1 Supported by Fondo de Apoyo a la Investigación, Universidad de San Luis Potosí, process # C12-FAI-03-37-37. 2 PhD, Full Professor, Facultad de Enfermería, Universidad Autónoma de San Luís Potosí, San Luís Potosí, San Luís Potosí, Mexico. 3 PhD, Full Professor, Departamento de Personalidad, Evaluación y Tratamiento Psicológico, Facultad de Psicología, Universidad de Salamanca, Salamanca, Spain...

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When (a) holds it is easy to characterize dissipativity in an explicit way. In fact it is easy to prove that the set of assumptions (a)-(b) is equivalent to (a)-(b*) with (b*) There exists R > 0 such that IorFi(t, Rei) d t < 0 ; 1 < i _ < 3 ; where le l,e2,e31 denotes the canonical basis of ~3. As a consequence of the theorem we obtain a result that is reminiscent of Massera 's theorem for plan...